The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy. in Seminars in thoracic and cardiovascular surgery / Semin Thorac Cardiovasc Surg. 2023 Spring;35(1):164-176. doi: 10.1053/j.semtcvs.2022.02.004. Epub 20
2023
ASL Città di Torino
AO Cuneo
ASL Cuneo 1
AOU Città della Salute di Torino
AOU Novara
AOU Alessandria
Tipo pubblicazione
Journal Article
Autori/Collaboratori (88)Vedi tutti...
Zaraca F
Ospedale di Bolzano, Bolzano, Italy.
Viti A
IRCCS Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
Voltolini L
AOUC Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.
et alii...
Abstract
The aim of this study was to assess the impact of BMI on perioperative outcomes in patients undergoing VATS lobectomy or segmentectomy. Data from 5088 patients undergoing VATS lobectomy or segmentectomy, included in the VATS Group Italian Registry, were collected. BMI (kg/m(2)) was categorized according to the WHO classes: underweight, normal, overweight, obese. The effects of BMI on outcomes (complications, 30-days mortality, DFS and OS) were evaluated with a linear regression model, and with a logistic regression model for binary endpoints. In overweight and obese patients, operative time increased with BMI value. Operating room time increased by 5.54 minutes (S.E. = 1.57) in overweight patients, and 33.12 minutes (S.E. = 10.26) in obese patients (P < 0.001). Compared to the other BMI classes, overweight patients were at the lowest risk of pulmonary, acute cardiac, surgical, major, and overall postoperative complications. In the overweight range, a BMI increase from 25 to 29.9 did not significantly affect the length of stay, nor the risk of any complications, except for renal complications (OR: 1.55; 95% CI: 1.07-2.24; P = 0.03), and it reduced the risk of prolonged air leak (OR: 0.8; 95% CI: 0.71-0.90; P < 0.001). 30-days mortality is higher in the underweight group compared to the others. We did not find any significant difference in DFS and OS. According to our results, obesity increases operating room time for VATS major lung resection. Overweight patients are at the lowest risk of pulmonary, acute cardiac, surgical, major, and overall postoperative complications following VATS resections. The risk of most postoperative complications progressively increases as the BMI deviates from the point at the lowest risk, towards both extremes of BMI values. Thirty days mortality is higher in the underweight group, with no differences in DFS and OS.
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PMID : 35182733
DOI : 10.1053/j.semtcvs.2022.02.004
Keywords
VATS; Thoracic surgery; Overweight paradox; Obesity paradox; Lung resection; Body Mass Index (BMI); Retrospective Studies; Postoperative Complications/etiology; Obesity/complications; Treatment Outcome; Thoracic Surgery, Video-Assisted/adverse effects; Pneumonectomy/adverse effects; Thinness/complications; Body Mass Index; Overweight/complications; Humans;