Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study. in Nature communications / Nat Commun. 2024 Sep 7;15(1):7835. doi: 10.1038/s41467-024-51679-x.
2024
AOU Città della Salute di Torino
Tipo pubblicazione
Journal Article
Autori/Collaboratori (41)Vedi tutti...
Thakral A
Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
Lee JJ
Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada. Jongwook.lee@utoronto.ca.
Hou T
Department of Otolaryngology - Head and Neck Surgery, Sinai Health System, Toronto, Ontario, Canada. Jongwook.lee@utoronto.ca.
et alii...
Abstract
HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases and 3469 controls. Lifetime smoking exposure, as measured by the Comprehensive Smoking Index (CSI), is associated with increased risk of both HPV-negative HNSCC (OR?=?3.03, 95%CI:1.75-5.24, P?=?7.00E-05) and HPV-positive HNSCC (OR?=?2.73, 95%CI:1.39-5.36, P?=?0.003). Drinks Per Week is also linked with increased risk of both HPV-negative HNSCC (OR?=?7.72, 95%CI:3.63-16.4, P?=?1.00E-07) and HPV-positive HNSCC (OR?=?2.66, 95%CI:1.06-6.68, P?=?0.038). Smoking and alcohol independently increase the risk of both HPV-positive and HPV-negative HNSCC. These findings have important implications for understanding the modifying risk factors between HNSCC subtypes.
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PMID : 39244563
DOI : 10.1038/s41467-024-51679-x
Keywords
Humans; Mendelian Randomization Analysis; Alcohol Drinking/adverse effects; Head and Neck Neoplasms/virology/genetics/epidemiology; Smoking/adverse effects; Papillomavirus Infections/virology/epidemiology; Squamous Cell Carcinoma of Head and Neck/virology/genetics/epidemiology; Male; Female; Risk Factors; Papillomaviridae/genetics; Middle Aged; Case-Control Studies; Polymorphism, Single Nucleotide;