Autologous microfragmented adipose tissue treatment of knee osteoarthritis demonstrates effectiveness in 68% of patients at 4-year follow-up. in Archives of orthopaedic and trauma surgery / Arch Orthop Trauma Surg. 2024 Sep;144(9):3925-3935. doi: 10.1007/s00402-023-05143-y. Epub 2024 Jan 1
2024
ASL Asti
AOU Città della Salute di Torino
Tipo pubblicazione
Journal Article
Autori/Collaboratori (7)Vedi tutti...
Ferracini R
Department of Orthopedics and Traumatology, Ospedale Koelliker, Corso Galileo Ferraris 247/255, 10134, Turin, Italy. riccardoferraciniweb@gmail.com.
Formica M
Department of Surgical Sciences (DISC), Orthopaedics and Traumatology Clinic, Ospedale Policlinico San Martino, University of Genoa, Largo Rosanna Benzi 10, 16132, Genova, Italy.
Castagnoli C
Department of General Surgery and Special Surgery, Burns Center Unit, Unit of Skin Bank, Via Zuretti 29, 10126, Turin, Italy.
et alii...
Abstract
BACKGROUND: Adipose tissue-derived stem cells are an interesting therapeutic option for early knee osteoarthritis (OA) treatment due to their high plasticity, easiness of harvesting and rapidity of administration. The aim of this study was to evaluate the medium-term effectiveness and safety of Microfragmented Autologous Fat Tissue (MFAT) injection treatment at 4-year follow-up and to investigate potential correlations among patients' pre-treatment clinical condition and clinical outcomes to identify possible predicting factors for procedure success or failure. PATIENTS AND METHODS: This is a prospective trial enrolling 46 patients with diagnosis of symptomatic knee OA and failure of previous conservative measures who underwent diagnostic arthroscopy and single autologous MFAT injection between June 2017 and July 2018. Patients were assessed with repeated clinical scoring systems at baseline, 6 months, 1 and 4 years after surgery. The evaluation included demographic characteristics, arthroscopic findings, and stem cell number from injected tissue. RESULTS: No major complications were reported during follow-up period and there was a significant increase of Lysholm knee score from baseline value of 61.7?±?13.8 to 79.5?±?16.9 at 4 years (p?
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PMID : 38212589
DOI : 10.1007/s00402-023-05143-y
Keywords
Adipose tissue-derived mesenchymal stem cells; Treatment Outcome; Injections, Intra-Articular; Stem Cell Transplantation/methods; Arthroscopy/methods; Aged; Transplantation, Autologous; Prospective Studies; Follow-Up Studies; Middle Aged; Female; Male; Adipose Tissue/transplantation; Osteoarthritis, Knee/therapy/surgery; Humans; Intra-articular injection; Knee osteoarthritis; Medium term follow-up;