Technical and Clinical Outcomes After Transcatheter Edge-to-Edge Repair of Mitral Regurgitation in Male and Female Patients: Is Equality Achieved? in Journal of the American Heart Association / J Am Heart Assoc. 2024 Jun 4;13(11):e032706. doi: 10.1161/JAHA.123.032706. Epub 2024 May 28.
2024
ASL Torino 4
Tipo pubblicazione
Multicenter Study
Autori/Collaboratori (19)Vedi tutti...
Biasco L
Department of Biomedical Sciences University of Italian Switzerland Lugano Switzerland.
Tersalvi G
Azienda Sanitaria Locale Torino 4 Turin Italy.
Klersy C
Division of Cardiology Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale Lugano Switzerland.
et alii...
Abstract
BACKGROUND: Currently, no clear impact of sex on short- and long-term survival following transcatheter edge-to-edge mitral valve repair (TEER) is evident, although no data are available on postprocedural life expectancy. Our aim was to assess sex-specific differences in outcomes of patients with mitral regurgitation (MR) treated by TEER. METHODS AND RESULTS: Short-term and 5-year outcomes in men and women undergoing TEER between 2011 and 2018 who were included in the large, multicenter, real-world MitraSwiss registry were analyzed. Outcomes were compared stratified by sex and according to MR cause (primary versus secondary). The impact of TEER on postprocedural life expectancy was estimated by relative survival analysis. Among 1142 patients aged 60 to 89?years, 39.8% were women. They were older, with fewer cardiovascular risk factors and lower functional capacity compared with men. Thirty-day mortality was higher in men than in women (3.3% versus 1.1%; odds ratio, 3.16 [95% CI, 1.16-10.7]; P=0.020). Five-year survival was comparable in both sexes (adjusted hazard ratio for 5-year mortality in men, 1.14 [95% CI, 0.90-1.44], P=0.275). Both men and women with either primary or secondary MR showed similar clinical efficacy over time. TEER provided high relative survival estimates among all groups, and fully restored predicted life expectancy in women with primary MR (5-year relative survival estimate, 97.4% [95% CI, 85.5-107.0]). CONCLUSIONS: TEER is not associated with increased short-term mortality in women, whereas 5-year outcomes are comparable between sexes. Moreover, TEER completely restored normal life expectancy in women with primary MR. A residual excess mortality persists in secondary MR, independently of sex.
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PMID : 38804217
DOI : 10.1161/JAHA.123.032706
Keywords
Humans; Mitral Valve Insufficiency/surgery/mortality/physiopathology; Female; Aged; Male; Aged, 80 and over; Middle Aged; Cardiac Catheterization; Sex Factors; Registries; Treatment Outcome; Heart Valve Prosthesis Implantation/adverse effects/mortality; Mitral Valve/surgery/diagnostic imaging/physiopathology; Risk Factors; Life Expectancy; Time Factors; edge?to?edge mitral valve repair; mitral regurgitation; mortality; percutaneous mitral valve repair; sex;