Increased prevalence of high-risk coronary plaques in metabolic dysfunction associated steatotic liver disease patients: A meta-analysis. in European journal of clinical investigation / Eur J Clin Invest. 2024 Sep;54(9):e14188. doi: 10.1111/eci.14188. Epub 2024 Feb 23.
2024
AOU Città della Salute di Torino
ASL Città di Torino
Tipo pubblicazione
Systematic Review
Autori/Collaboratori (17)Vedi tutti...
De Ferrari GM
Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini" Sapienza University of Rome, Rome, Italy.
Iannaccone M
Department of General Surgery, Surgical Specialties and Organ Transplantation "Paride Stefanini" Sapienza University of Rome, Rome, Italy.
Bugianesi E
Department of Clinical Internal, Anaesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
et alii...
Abstract
BACKGROUND: Metabolic dysfunction associated steatotic liver disease (MASLD) is associated with an increased risk of coronary artery disease. Computed Tomography Coronary Angiography (CTCA) can assess both the extent and the features of coronary plaques. We aimed to gather evidence about the prevalence and features of coronary plaques among MASLD patients. METHODS: PubMed, Scopus, and Google Scholar databases were searched for randomized controlled trials and adjusted observational studies assessing the prevalence and features of coronary plaques by means of CTCA in MASLD patients as compared with a control group. The prevalence of coronary stenosis (defined as >30% and >50% diameter of stenosis), of increasing coronary artery calcium (CAC) score and of high-risk features (namely low-attenuation plaques, napkin ring sign, spotty calcification and positive remodelling) in MASLD patients were the endpoints of interest. RESULTS: Twenty-four observational studies were included. MASLD was associated with an increased prevalence of critical coronary stenosis compared with controls (odds ratio [OR] 1.54, 95%CI 1.23-1.93). Increased values of CAC score were observed in MASLD patients (OR 1.35, 95%CI 1.02-1.78 and OR 2.26, 95%CI 1.57-3.23 for CAC score 0-100 and >100, respectively). An increased risk of 'high-risk' coronary plaques was observed in MASLD patients (OR 2.13, 95%CI 1.42-3.19). As high-risk features plaques, a higher prevalence of positive remodelling and spotty calcification characterize MASLD patients (OR 2.92, 95%CI 1.79-4.77 and OR 2.96, 95%CI 1.22-7.20). CONCLUSIONS: Patients with MASLD are at increased risk of developing critical coronary stenosis and coronary plaques characterized by high-risk features as detected by CTCA.
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PMID : 38396359
DOI : 10.1111/eci.14188
Keywords
Prevalence; Risk Factors; Vascular Calcification/diagnostic imaging/epidemiology; atherosclerosis; coronary plaques; metabolic?associated steatotic liver disease; coronary artery disease; computed tomography coronary angiography; Plaque, Atherosclerotic/diagnostic imaging/epidemiology/metabolism; Observational Studies as Topic; Metabolic Diseases/complications/epidemiology; Fatty Liver/epidemiology/etiology; Coronary Stenosis/epidemiology/diagnostic imaging; Coronary Artery Disease/epidemiology/diagnostic imaging; Coronary Angiography; Computed Tomography Angiography; Humans;