TORNA ALL’ELENCO

Impact of screening programme using the faecal immunochemical test on stage of colorectal cancer: Results from the IMPATTO study in International Journal of Cancer

2019
ASL Biella
AOU Città della Salute di Torino

Tipo pubblicazione

Article

Autori/Collaboratori (67)Vedi tutti...

Vicentini M

Zorzi M

Bovo E


et alii...

Abstract

To evaluate the impact of faecal immunochemical test (FIT) screening on stage distribution at diagnosis, and to estimate relative incidence rates by stage in screened at first and subsequent rounds vs. unscreened. We included all incident cases occurring in 2000–2008 in 50- to 71-year-olds residing in areas with an FIT-screening programme. Multinomial logistic models were computed to estimate the relative risk ratio (RRR) of stages I and IV, compared to stage II + III, adjusting for age, sex, geographical area, and incidence year. Proportions were then used to estimate incidence rate ratios (IRR) by stage for screened subjects at the first and at subsequent rounds vs. unscreened subjects, applying the expected changes in overall incidence during screening phases. 11,663 cancers were included: 5965 in not-invited and 5,698 in invited subjects, 3,425 of whom attendees. Compared to not-invited, invited subjects had RRR 2.04 (95% CI: 1.84; 2.46) of stage I and RRR 0.77 (95% CI: 0.69; 0.87) of stage IV. Differences were stronger comparing attendees vs. nonattendees. Interval cancers were more frequently stage I compared to non-invited (RRR 1.54; 95% CI: 1.15; 2.04), but there was no difference for stage IV. IRRs in screened at first round vs. unscreened were 4.6 (95% CI: 4.2; 5.1), 1.4 (95% CI: 1.3; 1.5) and 0.7 (95% CI: 0.6; 0.9) for stages I, II + III and IV, respectively; in the following rounds the IRRs of screened vs. unscreened were 1.4 (95% CI: 1.2; 1.6), 0.8 (95% CI: 0.7; 0.9) and 0.3 (95% CI: 0.1; 0.4) for stages I, II + III and IV, respectively. FIT screening reduces the incidence of metastatic cancers by about 70% after the first round.

PMID : 30585621

DOI : 10.1002/ijc.32089

Keywords

risk factor; priority journal; multivariate logistic regression analysis; metastasis; medical history; mathematical analysis; male; major clinical study; immunochemistry; human tissue; human; geography; gender; female; feces analysis; fecal immunchemical test; controlled study; colorectal cancer; clinical study; cancer staging; cancer screening; cancer incidence; cancer classification; article; aged; age; adult; immunochemistry analyzer;