TORNA ALL’ELENCO

Exhaled nitric oxide as predictor of bronchial hyperresponsiveness to methacholine in subjects with respiratory symptoms in European Respiratory Journal

2017
ASL Città di Torino

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (6)Vedi tutti...

Pizzimenti S
RSA Villa Serena, Bologna (BO), Italy
Piccioni P
RSA Villa Serena, Bologna (BO), Italy
Heffler E
RSA Villa Serena, Bologna (BO), Italy

et alii...

Abstract

Background: Exhaled nitric oxide (FENO) is a non-invasive method to assess Th2-driven airway inflammation. We analyzed if FENO can predict bronchial hyperresponsiveness to methacholine (BHR) among patients with respiratory symptoms and if this prediction was different if subjects were IgE sensitized or not. Methods: All non-smoking consecutive patients attending the Outpatients' Clinic of CPA, Turin, Italy with a suspicion of asthma in a 12 months' period performed FENO and methacholine provocation test. Atopy was evaluated in the majority of the subjects by skin prick test or IgE analysis. Results: A total of 196 patients were enrolled into the study and information on atopic sensitization was available in 166. Exhaled nitric oxide [geometric mean (95% confidence interval] was increased in subjects who received asthma diagnosis (n=79), 41.0 (95% CI, 34.7-48.6) vs 22.5 (95% CI, 19.7-25.6), p<0.001, as in subjects with a positive methacholine challenge (defined as PD20<800 mcg, n=30) with 43.4 (34.2, 55.3) vs 26.8 (23.8, 30.2), p<0.001. Stratifying for atopy, subjects with BHR (defined as PD20<=2000 mcg) had higher FeNO levels than subject without BHR both among atopic and nonatopic subjects (p<0.001) and this association was consistent also after adjusting for gender, age, lung function and the presence of cough as respiratory symptom (p<0.001). Conclusion: Increased exhaled NO was found to be related to BHR to methacholine in unselected subjects with respiratory symptoms suggestive of asthma. This was found disregarding allergic status of the subject or presence of cough as presenting respiratory symptom.

DOI : 10.1183/1393003.congress-2017.PA3984

Keywords

Italy; human; gender; fractional exhaled nitric oxide; female; drug therapy; diagnosis; coughing; controlled study; conference abstract; bronchus hyperreactivity; atopy; asthma; adult; nitric oxide; methacholine; immunoglobulin E; endogenous compound; lung function; major clinical study; male; outpatient; prediction; prick test; provocation test; sensitization;