TORNA ALL’ELENCO

Predictors of beta cell dysfunction in type 2 diabetes: The Beta Decline study in Diabetologia

2013
ASL Asti
ASL Torino 5

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (12)Vedi tutti...

Russo GT
Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Ferrarotto, Santa Marta, S. Bambino, Dipartimento di Medicina, Catania, Italy
Arcangeli A
Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Ferrarotto, Santa Marta, S. Bambino, Dipartimento di Medicina, Catania, Italy
Cercone S
Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Ferrarotto, Santa Marta, S. Bambino, Dipartimento di Medicina, Catania, Italy

et alii...

Abstract

Background and aims: Beta-cell dysfunction is an early step in the natural history of type 2 diabetes. However, its progression rate is variable and potentially influenced by several factors, including hypoglycaemic drugs. BetaDecline is an Italian multi-center prospective study, which has the aim to evaluate the association of beta-cell dysfunction with several clinical variables in a large cohort of type 2 diabetic subjects on stable treatment with oral hypoglycaemic drugs (OHAs) or diet only for more than one year. Materials and methods: Clinical and lifestyle data were collected in all participants. Beta-cell dysfunction has been evaluated by the proinsulin/insulin ratio (P/I) and HOMA-B index; the degree of insulin resistance by HOMAIR model; common metabolic parameters, as well as fasting serum levels of NEFA, IL-6 and hsCRP were also measured. Results: Overall, type 2 diabetic subjects participating to our study (n=508, 58.7% men and 41.3% women; mean age 63 years) were overweight (mean BMI 29.2 kg/m2, mean waist circumference 102 cm) with an acceptable metabolic control (mean HbA1c 7.2 %), and a mean diabetes duration of 8.8 years. Of these, 84% was currently treated with metformin, alone (39%) or in combination with other OHAs (45%); 35% was on sulphonylureas (SU), 10% on glytazones, 16% on glinides, 2% on acarbose and 5,5% of them was on diet only. At baseline, the PI/I ratio showed an inverse linear association with male gender, BMI, total cholesterol (T-C), LDL-C, HDL-C and hsCRP serum levels, and a positive linear association with HbA1c, FBG and triglycerides levels (P trend<0.05 for all comparisons); whereas no significant differences were noted in IL-6 and NEFA concentrations, as well as in systolic and diastolic blood pressure values across quartiles of P/I ratio. Both HOMA-B and HOMA IR values progressively decreased across the increasing P/I ratio quartiles (P<0.0001, both). Secretagogues (SU e glinides) use was significantly greater in the

DOI : 10.1007/s00125-013-3012-z

Keywords

cellular secretion; outpatient; metabolic parameters; cholesterol blood level; gender; lifestyle; diet restriction; female; diastolic blood pressure; model; prospective study; risk; waist circumference; multivariate analysis; obesity; insulin resistance; metabolic regulation; history; blood level; diet; diabetic patient; male; human; diabetes mellitus; non insulin dependent diabetes mellitus; low density lipoprotein; high density lipoprotein; antihypertensive agent; triacylglycerol; metformin; acarbose; hemoglobin A1c; interleukin 6;