TORNA ALL’ELENCO

Prevalence of anaemia in inflammatory bowel disease: Preliminary results of the observational italian multicentre IG-IBD study ridart 1 in United European Gastroenterology Journal

2018
AOU Città della Salute di Torino
ASL Torino 3

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (48)Vedi tutti...

Mengoli C

Fontana R

Valerii C


et alii...

Abstract

Introduction: Anaemia is the most common extra-intestinal manifestation in inflammatory bowel disease (IBD). Aims and Methods: The RIDART 1 is an independent, observational, multicentre study, promoted by the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) with the primary aim to define the prevalence of anaemia in an unselected population of Italian patients with IBD. 3220 unselected Italian patients with IBD were included. The follow-up of anaemic patients was extended up to six months after recruitment in order to evaluate how anaemic patients were treated and if the ECCO guidelines for the treatment of iron deficiency anaemia in IBD were correctly applied. Here we showed preliminary results describing the main features of IBD patients with anaemia in terms of demography, disease activity, anaemia pathogenesis and severity 20 months after starting the study. Results: Of the 3220 IBD patients included, 392 (12.2%) had anaemia. No difference between anaemic and non-anaemic subjects were observed as far as patient age, gender and disease duration. Body mass index was significantly (p=0.0051) lower in the anaemic group (22±2.5 kg/m2) compared with the non-anaemic one (24±2 kg/m2). In most cases (86%) anaemia was mild (Hb?9.5 g/dL), and only 2% of patients had severe anaemia (Hb<8.0 g/dL). Hb was lower in patients with active disease and correlated significantly with CDAI in Crohn's disease (p=0.0182) and CAI in ulcerative colitis (p=0.0021). An isolated iron deficiency was responsible for 61.7% of anaemic cases, while the remaining cases had anaemia of chronic disease (12.8%), vitamin deficiencies (2.8%), and various combinations of iron and/or vitamin deficiencies and inflammation (22.7%). Conclusion: The lower prevalence of anaemia in RIDART1 (12.2%) in comparison to that reported in previous European studies may be due to the fact that, in recent years, more attention is paid to the impact of anaemia in IBD patients, and both anaemia

DOI : 10.1177/2050640618792819

Keywords

vitamin deficiency; ulcerative colitis; preliminary data; prevalence; practice guideline; male; multicenter study; major clinical study; Italian (citizen); iron deficiency anemia; gender; human; follow up; female; demography; drug combination; Crohn disease; conference abstract; clinical evaluation; chronic disease; attention; body mass; adult; iron;