TORNA ALL’ELENCO

Involvement in treatment decisions, desire for prognostic information and quality of life in high-risk myelodysplastic syndromes: The physician's perspective in Leukemia Research

2011
ASL Torino 4

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (31)Vedi tutti...

Efficace F
RSA Villa Serena, Bologna (BO), Italy
Alimena G
RSA Villa Serena, Bologna (BO), Italy
Voso MT
RSA Villa Serena, Bologna (BO), Italy

et alii...

Abstract

Background: No evidence-based data currently exist on a number of key issues revolving around the clinical decision-making process in patients with high-risk myelodysplastic syndromes (MDS). Aim: The purpose of this analysis is to investigate the proportion of patients who requested explicit prognostic information at the time of diagnosis and to investigate factors associated with the relevance, according to the physician's view, of involving patients in the clinical decision-making process. Patients and Methods: An international prospective observational study is being conducted in several countries, to investigate a number of issues related to the clinical decision-making process and to obtain prospective data on patient reported QoL and symptom burden, in newly diagnosed MDS patients with intermediate-2 or high-risk IPSS score. Overall there are 160 patients registered on the web-data collection system. At the time of enrollment, physicians were requested to complete a Survey concerning their encounter with the patient. A number of information was collected including: whether they received a request for explicit prognostic information from their patients and their opinion on the extent to which they felt it was important to involve the patient in making treatment decisions. They were also asked to rate their patients' QoL. Descriptive statics and logistic regression models were used. A number of covariates were controlled in the analyses: age, gender, performance status, IPSS risk score category, having had a previous MDS, QoL (physician-reported) and comorbidty (“Hematopoietic Cell Transplantation-Comorbidity index”). Results: Thirty four percent of patients were females and 65% were males (median age of patients was 71 years). Seventy-seven percent were diagnosed with IPSS int-2 risk score and 23% with IPSS high risk score; -51% had at least 1 comorbidity-. According to physicians' reports, 63% of patients explicitly requested prognostic information

DOI : 10.1016/S0145-2126(11)70149-7

Keywords

evidence based practice; gender; information processing; observational study; health; comorbidity; diagnosis; model; logistic regression analysis; clinical decision making; patient; quality of life; myelodysplastic syndrome; risk; physician; cell transplantation; female; male; survival; decision making; hematopoietic cell;