TORNA ALL’ELENCO

Time trends and case fatality rate of pulmonary embolism during 11 years of observation in northwestern Italy in Journal of Thrombosis and Haemostasis

2015
AO Cuneo
ASL Città di Torino

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (6)Vedi tutti...

Dentali F
Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Ferrarotto, Santa Marta, S. Bambino, Dipartimento di Medicina, Catania, Italy
Ageno W
Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Ferrarotto, Santa Marta, S. Bambino, Dipartimento di Medicina, Catania, Italy
Pomero F
Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Ferrarotto, Santa Marta, S. Bambino, Dipartimento di Medicina, Catania, Italy

et alii...

Abstract

Background: Pulmonary embolism (PE) is a common and increasingly diagnosed disorder with high mortality and morbidity rates. However, population-based information on its incidence and prognosis remains limited. Aims: To better assess the incidence and the short term prognosis of PE on a large population during a long period of abservation. Methods: We conducted a large epidemiology study collecting data on hospitalization for PE (from 2002 to 2012) in a population of about 13 millions people in Northwestern Italy. Patients were identified using the ICD-9-CM codes: 415.11, 415.19; gender and age specific incidence rate of PE during the study period were estimated using the resident population for each year of the study. Furthermore, time trends in the in-hospital PE-related mortality and case fatality rate were calculated. Results were adjusted for possible confounders. Results: 60,853 patients with a first event of PE were included in the analysis. The overall crude incidence rate for the entire study period was 55.4 and 40.6 events per year per 100,000 inhabitants for women and men, respectively (P < 0.001). This difference completely disappeared when the incidence rates for the two populations were standardized according to age. The incidence of PE significantly increased in both genders during the study period. In-hospital case fatality rate significantly decreased throughout the study period (P < 0.001) in women (from 15.6% to 10.2%) and in men (from 17.6% to 10.1%). The observed decrease of the in-hospital case-fatality throughout the study period remained significant also after adjustment for possible confounders. Conclusion: Time trends over an 11-year period show an increasing incidence of PE, but a significant reduction in mortality during hospitalization. Reduction in the case fatality rate remained significant after adjustment for possible confounders.

DOI : 10.1111/jth.12993

Keywords

clinical laboratory; mortality; gender; hypocapnia; female; risk; blood gas analysis; hemostasis; thrombosis; society; chronic obstructive lung disease; human; patient; lung embolism; risk factor; prevalence; computer assisted tomography; population; diagnosis; sample size; multivariate analysis; multicenter study; prognosis; dyspnea;