TORNA ALL’ELENCO

Apoe genotype and onset of cognitive impairment in ALS: No correlation. A population-based study in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

2015
AOU Città della Salute di Torino

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (11)Vedi tutti...

Calvo A

Brunetti M

Barberis M


et alii...

Abstract

Background: The relationship between the apolipoprotein E (ApoE) ?4 genotype and an increased risk of developing Alzheimer's disease (AD) is well established. In frontotemporal dementia (FTD), the second most frequent dementia disorder, an increased risk in subjects carrying the ApoE ?4 genotype has also been reported. No data are available the ApoE ?4 genotype and the risk of developing FTD in ALS patients. Objectives: To assess the relationship between ApoE genotypes and ALS with comorbid FTD in a population-based series of Italian ALS patients. Methods: A consecutive series of ALS patients incident in Piemonte underwent an extensive cognitive evaluation. Patients were classified according to the Strong et al criteria in ALS-FTD, ALS with cognitive impairment (ALS-Ci), ALS with behavioural impairment (ALS-Bi) and ALS cognitively normal (ALS-CN). ApoE genotypes were assessed with the standard methodology. A total of 179 age- and gender-matched population-based controls were also genotyped for ApoE. Results: A total of 282 ALS patients have been included in the study: 141 (50%) were classified as ALS-CN; 85 (30.2%) as ALS-Ci; 18 (6.4%) as ALS-Bi and 38 (13.5%) as ALS-FTD. ApoE ?4 genotype was ?4 and ?2 genotypes in ALS patients were not related to their site and age at onset. The frequency of ApoE ?4 genotype in ALS cases (13.6%) was similar to that observed to population-based controls (12.2%) (p=0.41). The frequency of ApoE ?2 genotype in ALS cases (12.4%) was similar to that of controls (12.4%). Conclusions: We did not find any correlation between ApoE genotype and the risk of developing FTD in our series of population-based ALS patients. While ApoE is an established risk for AD and pure FTD.

DOI : 10.3109/21678421.2015.1098813/0023

Keywords

apolipoprotein E; cognitive defect; population; genotype; human; patient; risk; dementia; frontotemporal dementia; methodology; diseases; gender; onset age; Alzheimer disease;