TORNA ALL’ELENCO

Effectiveness of first-line h. pylori eradication therapy according to the daily statin-use: Analysis of the european registry on h. pylori management (HP-EuReg) in United European Gastroenterology Journal

2020
AOU Città della Salute di Torino

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (31)Vedi tutti...

Caldas M

Perez-Aisa A

Tepes B


et alii...

Abstract

Introduction: The use of statins combined with antibiotics has been suggested as a strategy to increase the effectiveness of Helicobacter pylori treatments, mainly based on their anti-inflammatory characteristics. However, evidence published so far still remains scarce. Aims & Methods: Aim: To analyse the impact of the daily use of statins in the effectiveness of H. pylori first-line therapies in a European cohort of patients. Methods: Multicentre prospective non-interventional study of the clinical practice of European gastroenterologists of the European Registry on H. pylori Management (Hp-EuReg). Patients were collected at AEG-REDCap e- CRF from 2013 to December 2019. Records of naive patients containing information about the statins' use were collected and only those daily statin users were considered for current analysis. Modified intention-to-treat (mITT) analysis was performed to evaluate the treatment effectiveness between statin and non-statin users. A multivariate analysis was performed on the overall population and for each treatment scheme, where the dependent variable was the eradication rate by mITT. The independent factors evaluated were: age, gender, presence of ulcer, proton pump inhibitor dose, therapy duration, compliance and use of statins. Results: Overall, 7,687 patients received an empirical first-line therapy. Median age was 56 years, 60% were women and 18% had peptic ulcer disease. From those, 1,895 (25%) were daily statins-users: 45% used simvastatin, 35% atorvastatin, 11% rosuvastatin and 9% other statins. Univariate analysis showed no differences in the treatment effectiveness of the statin-users group versus no statin-users on the overall population, neither by therapy prescribed (Table). Concerning the multivariate analysis, the daily statin-use in those patients receiving a standard triple therapy with clarithromycin and amoxicillin was associated with lower treatment effectiveness (OR=0.8; 95%CI: 0.6-0.99). This negative associ

DOI : 10.1177/2050640620927345

Keywords

human; Helicobacter pylori; gender; gastroenterologist; female; European; eradication therapy; drug therapy; drug combination; dependent variable; controlled study; conference abstract; cohort analysis; clinical practice; adult; tetracycline; simvastatin; rosuvastatin; proton pump inhibitor; metronidazole; clarithromycin; atorvastatin; amoxicillin; major clinical study; male; middle aged; multicenter study; nonhuman; peptic ulcer; prospective study; treatment duration; univariate analysis;