TORNA ALL’ELENCO

Age of first arrhythmic event in Brugada syndrome: Data from the survey on arrhythmic events in Brugada syndrome (SABRUS) in 678 patients in Journal of Interventional Cardiac Electrophysiology

2019
AOU Città della Salute di Torino
ASL Asti

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (47)Vedi tutti...

Milman A

Andorin A

Gourraud J-B


et alii...

Abstract

Background: Data on the age at first arrhythmic event (AE) in Brugada syndrome (BrS) are from limited patient cohorts. The aim of this study is twofold: 1) to define the age of first AE in a large cohort of BrS-patients; 2) assess the influence of the mode of AE documentation, gender and ethnicity on the age of first AE. Methods and Results: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 BrS-patients (91.3% males) with first AE documented at time of aborted cardiac arrest (Group A, n=426) or after prophylactic ICD-implantation (Group B, n=252). The vast majority (94.2%) of the patients were 16-70 years old at the time of AE while pediatric (< 16 years) and elderly patients (> 70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38-48 years (mean 41.9+14.8, range 0.27 to 84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1+13.2 vs. 39.4+15.0 years, P< 0.001). In adult patients (> 16 years), females experienced AE 6.5 years later than males (P=0.003). Caucasians and Asians exhibited their AE at the same median age (43 years). Conclusions: SABRUS presents the first analysis on the age distribution of AE in BrS, suggesting 2 age cut-offs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient gender and ethnic origin on the age of AE. [Table Presented].

DOI : 10.1007/s10840-019-00559-2

Keywords

adolescent; adult; age distribution; aged; Asian; Brugada syndrome; Caucasian; child; cohort analysis; conference abstract; controlled study; decision making; documentation; ethnic group; ethnicity; female; gender; heart arrest; human; implantation; major clinical study; male; multicenter study; very elderly;