TORNA ALL’ELENCO

Mortality data in TTS: New insights from the intertak Registry in European Heart Journal

2017
AOU Città della Salute di Torino

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (7)Vedi tutti...

Sarcon A

Ghadri J

Cammann V


et alii...

Abstract

Background: Long-term outcomes of patients with Takotsubo syndrome (TTS) remains a controversial issue, given scarcity of data available in the current literature. As such, investigating and elucidating these outcomes can aid us in better estimating the real risk of this disease. Purpose: To investigate the long-term outcomes of patients with TTS according to a novel classification, and to compare long-term mortality of these patients to an age- and gender matched cohort of ACS patients. Methods: Patients included in the present study were taken from the International Takotsubo Registry (InterTAK Registry). Details of the methods of this study were previously outlined by Templin et. al. 09/2015 NEJM. According to a new TTS classification patients were assigned into different types, I: TTS related to emotional stress, II: TTS related to physical stress, IIa: TTS secondary to medical conditions and procedures, IIb: TTS secondary to neurologic diseases, IIc: TTS secondary to pheocromocytoma, III: TTS without stress. Long-term outcomes of various TTS types were analysed. Long-term mortality of patients with TTS was compared to an age- and gender matched cohort of patients with ACS. Results: Of 1750 TTS patients of the InterTAK Registry, 455 were included and compared to 455 ACS patients. Detailed selection of TTS and ACS patients have already been published elsewhere. Comparison of long-term mortality according to the different classification types (I-IV) of TTS demonstrated a substantial difference in outcomes (P<0.001). Patients with TTS type I had the most favorable prognosis, while patients with type II had the highest mortality rate. Long-term mortality analysis between TTS and ACS was similar (P=0.47). Conclusion: TTS encompasses a heterogeneous spectrum of acute heart failure syndrome and a thorough clinical acumen is required to distinguish among different TTS types as mortality is significantly different. TTS is a serious condition and has a similar long

DOI : 10.1093/eurheartj/ehx502.P1079

Keywords

acute heart failure; adult; classification; cohort analysis; conference abstract; controlled study; emotional stress; female; gender; human; major clinical study; male; mortality rate; mortality risk; neurologic disease; physical stress; prognosis; register; risk assessment; takotsubo cardiomyopathy;