TORNA ALL’ELENCO

Clustering acute heart failure patients according diastolic dysfunction degree: A single centre experience in Giornale Italiano di Cardiologia

2020
ASL Cuneo 1

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (5)Vedi tutti...

Feola M

Testa M

Rossi A


et alii...

Abstract

Background. Different studies in heart failure (HF) setting evaluated diastolic dysfunction degree through echocardiography. The interest by researchers in this topic leads to better recognize diastolic dysfunction favouring the standardization of its definition through a consensus document.1 In this study we would like to identify the phenotype of acute heart failure (AHF) patients according diastolic dysfunction degree. Methods. This is an observational retrospective study enrolling patients with diagnosis of acute heart failure (AHF) de novo or not, in sinus rhythm admitted to our department from June 2015 to October 2018 within 12 hours from emergency department admission. Patients underwent to echocardiography to assess diastolic dysfunction degree: normal diastolic function, diastolic dysfunction grade I, grade II e and grade III according the recent consensus document.1 Patients were followed for one year after hospital discharge for the composite outcome of HF rehospitalization and cardiovascular death through one year. Results. A total of 277 AHF patients in sinus rhythm were included in this analysis. Median age was 79[71-84] years, median of left ventricular ejection fraction (LVEF) was 40 [30-50]% and the median of serum levels of NTproBNP was 7871 [3180-17025] pg/ml. 68% of patients had normal diastolic function, 12% had diastolic dysfunction grade I, 10% grade II and 10% grade III. Among groups of diastolic function, no differences statistically significant were found in terms of age, gender, comorbidities, length of hospital stay, renal function and PASP. Patients with severe diastolic dysfunction (grade III) demonstrated higher admission NTproBNP levels (grade III 15538[8052-33724]; vs grade II 5428 [3107-11654]; vs grade I 8193[1740-17756]; vs normal: 7611 [3223-15245] pg/ml; p=0.008) with respect to other groups. Moreover, patients with diastolic dysfunction grade III showed lower median values of LVEF (grade III 27 [21-35]; vs grade II 40 [

Keywords

tricuspid annular plane systolic excursion; standardization; sinus rhythm; phenotype; retrospective study; male; major clinical study; kidney function; human tissue; human; hospitalization; hospital readmission; hospital mortality; hospital discharge; heart right ventricle failure; heart left ventricle ejection fraction; gender; female; emergency ward; echocardiography; diastolic dysfunction; controlled study; consensus; conference abstract; comorbidity; cardiovascular mortality; aged; acute heart failure;