TORNA ALL’ELENCO

Gender differences in acute coronary syndromes patterns during the COVID-19 outbreak in American Journal of Cardiovascular Disease

2020
AOU Città della Salute di Torino
ASL Città di Torino
ASL Torino 4
ASL Asti
ASL Vercelli
ASL Cuneo 1
AOU Alessandria

Tipo pubblicazione

Article

Autori/Collaboratori (33)Vedi tutti...

Amoroso GR
Department of Human Pathology of Adult and Childhood Gaetano Barresi, Unit of Pediatric Surgery, University of Messina, Messina, Italy
Patti G
Department of Human Pathology of Adult and Childhood Gaetano Barresi, Unit of Pediatric Surgery, University of Messina, Messina, Italy
Mancone M
Department of Human Pathology of Adult and Childhood Gaetano Barresi, Unit of Pediatric Surgery, University of Messina, Messina, Italy

et alii...

Abstract

Background: Mortality from acute coronary syndromes (ACS) is strictly related to early management. As female patients usually experience longer delays before diagnosis and treatment, we assessed whether women were more affected by the dramatic drop in hospital admissions for ACS during the Covid-19 pandemic. Methods: We performed a retrospective analysis of clinical and angiographic characteristics of consecutive patients who were admitted for ACS at 15 hospitals in Northern Italy comparing men and women data. The study period was defined as the time between the first confirmed case of Covid-19 in Italy (February 20, 2020) and March 31, 2020. We compared hospitalization rates between the study period and two control periods: the corresponding period during the previous year (February 20 to March 31, 2019) and the earlier period during the same year (January 1 to February 19, 2020). Incidence rate ratios comparing the study period with each of the control periods were calculated with the use of Poisson regression. Results: Of the 547 patients who were hospitalized for ACS during the study period, only 127 (23%) were females, accounting for a mean of 3.1 admissions per day, while ACS hospitalized males were 420, with a mean of 10.2 admissions per day. There was a significant decrease driven by a similar reduction in ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) diagnosis in both sexes compared to the control periods. A trend toward a greater reduction in admitted females was shown in the intra-year control period (46% admission reduction in females vs 37% in males, with females accounting for 26% of ACS, P=0.10) and a significant reduction when compared to the previous year control period (40% admission reduction in females vs 23% in males, with females accounting for 28% of ACS, P=0.03), mainly related to Unstable Angina diagnosis. Conclusion: The Covid-19 pandemic period closed the gap between m

Keywords

ST segment elevation myocardial infarction; risk factor; sex difference; retrospective study; prevalence; percutaneous coronary intervention; pandemic; multicenter study; observational study; non ST segment elevation myocardial infarction; male; ischemic heart disease; human; hospitalization; hospital mortality; gender; follow up; female; coronary angiography; coronavirus disease 2019; cardiovascular mortality; article; adult; acute coronary syndrome;