TORNA ALL’ELENCO

The protective role of diabetes on developing amyotrophic lateral sclerosis in European Journal of Neurology

2017
ASL Torino 3

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (6)Vedi tutti...

D'Ovidio F

D'Errico A

Carnà P


et alii...

Abstract

Background and aims: The literature on the association between diabetes and Amyotrophic Lateral Sclerosis (ALS) produced contrasting results. This study was developed in order to assess the role of diabetes on the risk of developing ALS. Methods: The study population was represented by all residents in Turin (Italy) in 1995, already present at 1991 Census, older than 14 years (n=752,863), followed up for diabetes and ALS occurrence from 1996 to 2014. Presence of diabetes was ascertained through two Piedmont regional sources: the Diabetes Registry and the Drugs Prescriptions Archive, both active or of acceptable quality from 1996. The risk of ALS was estimated using the Piedmont and Valle d'Aosta ALS Registry (PARALS). The association of diabetes and antidiabetic drugs, considered as timedependent variables, with ALS onset was estimated through Huber-White sandwich multivariate Poisson regression models adjusted for age, gender, education and marital status. Results: During the follow-up, 447 subjects developed ALS, of whom 14 from the diabetes registry and 22 from antidiabetic drugs archive. Both diabetes diagnosed, and antidiabetic drugs prescribed, more than one year before ALS onset, approximately halved the risk of ALS. Among antidiabetic drugs, the association between ALS and metformin, which was the most prescribed drug, was similar to the risk estimated for overall antidiabetics. Conclusion: The study results support a protective role of diabetes or antidiabetics toward ALS.

DOI : 10.1111/ene.13368

Keywords

metformin; adolescent; amyotrophic lateral sclerosis; diabetes mellitus; diagnosis; disease model; education; female; follow up; gender; human; information center; Italy; major clinical study; male; marriage; prescription; register; resident; statistical model;