TORNA ALL’ELENCO

Safety of uSCIT-MPL-4: Prevalence and risk factors of systemic reactions in real-life in Allergy: European Journal of Allergy and Clinical Immunology

2014
AO Ordine Mauriziano

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (10)Vedi tutti...

Caminati M

Guerriero M

Stefanizzi G


et alii...

Abstract

Background: The risk of systemic reactions (SRs) remains a major drawback of subcutaneous allergen immunotherapy (SCIT) for allergic respiratory disease. In fact though the overall safety of SCIT is documented it should be proved for the single extracts of each brand through a uniform SRs grading system. We aimed at assessing safety of uSCIT-MPL-4 (allergoid adjuvanted by monophosphoryl lipid A) in real-life. Method: This perspective survey involved 12 Allergy Units in Italy. Patients affected by allergic rhinitis (AR) and/or asthma (AA) and treated with uSCIT-MPL-4 were enrolled and followed-up for 1 year. SRs were registered according to the World Allergy Organization SCIT SRs grading system. The association between SRs and patient related (sex, age, disease type and severity, previous local reactions (LRs)) and SCIT related (allergen, schedule) factors was also evaluated by multivariate logistic regression. Results: Overall 2929 patients (male: 38.5%; female: 61.5%; mean (SD) age: 32.8 years (14.4)) were included. 83.4% were affected by AR with or without AA. AR and AA alone were observed in 36.1% and 8.7% of patients respectively; in 47.3% both the diseases were present. The distribution of prescribed extracts was as follows: grass 45.5%; parietaria 19%; ragweed 15.4%; trees 8.5%; allergen mix 5%; olive 4.10%; birch 2.4%; mugwort 0.03%. Poly-sensitisation was detected in 46.7% of patients. Grade 0,1, 2, 3 and 4 SRs were observed respectively in 3.3%, 1.5% 0.31%, 0.07% and 0.07% of patients. Epinephrine was used in five cases (0.17%). Female gender and severity of AR (ARIA classification) were significantly associated with Grade 0 SRs (OR = 2.67; CI95% = 1.65-4.28; P = 0.0001). A significant association was detected between Grade =1 SRs and: i) female gender (OR = 2.56; CI95% = 1.27-5.16; P = 0.009); ii) treatment schedule (number of doses) (OR = 1.32; CI95% = 1.06-1.63; P = 0.012); iii) previous LRs (OR = 5.80; CI95% = 2.53-13.30; P = 0.0001). No signific

DOI : 10.1111/all.12493

Keywords

allergy; risk factor; prevalence; epinephrine; lapretolimod; allergen; clinical immunology; safety; human; patient; female; gender; risk; allergic rhinitis; respiratory tract disease; birch; immunotherapy; olive; asthma; tree; Parietaria; grass; diseases; male; ragweed; logistic regression analysis; Artemisia vulgaris; Italy; classification; register;