Biomonitoring of a population exposed to pcb and dioxin near a steel plant in Susa Valley, Italy in Epidemiology
2012
ARPA Piemonte
Tipo pubblicazione
Conference Abstract
Autori/Collaboratori (4)Vedi tutti...
Cadum E
Chiusolo M
Ivaldi C
et alii...
Abstract
Background: Few studies are available on human biomonitoring in population exposed to PCB and dioxins. Objectives: To assess the effects on selected biological parameters in a sample of population resident near a steel plant in Piedmont, Italy, polluted by metals, PCB and dioxins. Materials and Methods: 244 people, 125 living in an area exposed to industrial pollution of a steel plant and 119 living in a non exposed area (controls), were sampled from the general population in the Susa Valley in Piedmont, Italy. The main pollutants present in the industrial emissions were metals, PCB and dioxins. Every subject compiled a questionnaire on smoking, alcohol consumption and dietetic habit. Ematochemical general parameters, hormones and PCB levels were measured in blood of every subject. The risk of selected reported pathologies in relation to PCB levels was measured in term of Odds Ratio. Results: No statistical significant differences were found between the exposed and unexposed subjects for the controlled parameters. PCB levels were correlated with age, gender and alcohol consumption. Nevertheless the values of PCB among the exposed were higher then among the unexposed (2.30 vs 1.90), as well as, systematically, other general parameters studied (cholesterol, glycaemia, bilirubin, creatinine, triglycerides) and hormones (thyrotropin, thyroxin, cortisol, ACTH, LH, FSH). Endometriosis was the only pathology that showed a significantly higher OR among subjects showing higher PCB levels. Conclusions: The power of the study was unable to show statistically significant differences among people exposed to PCB and dioxin emissions, even if a general pattern of altered parameters was found.
DOI : 10.1097/01.ede.0000417226.51483.39
Keywords
dioxin; steel; hormone; polychlorinated biphenyl; metal; hydrocortisone; thyroxine; thyrotropin; triacylglycerol; creatinine; bilirubin; cholesterol; follitropin; corticotropin; biological monitoring; endometriosis; plant; population; Italy; society; epidemiology; parameters; human; risk; pathology; alcohol consumption; blood; habit; pollution; smoking; questionnaire; pollutant; glucose blood level; gender;