Sarcopenia in chronic advanced liver diseases: A sex-oriented analysis of the literature. in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver / Dig Liver Dis. 2022 Aug;54(8):997-1006. doi: 10.1016/j.dld.2021.10.010. Epub 2021 Nov 15.
2022
AOU Città della Salute di Torino
Tipo pubblicazione
Review
Autori/Collaboratori (12)Vedi tutti...
Zanetto A
Multivisceral Transplant Unit, Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
Morisco F
Department of Clinical Medicine and Surgery, Gastroenterology Unit, University of Napoli Federico II", Via S. Pansini, 5, Napoli 80131, Italy.
Burra P
Multivisceral Transplant Unit, Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
et alii...
Abstract
Sarcopenia, defined as progressive and generalized loss of muscle mass and strength, is common in chronic liver disease. It significantly impacts the quality of life and increases the risk of liver-related complications and mortality in cirrhotic patients. Moreover, recent studies showed a negative impact of sarcopenia on patients awaiting liver transplantation (LT), on post-LT outcomes, and on response to hepatocellular carcinoma therapies. Data about the influence of sex on the incidence, prevalence, diagnosis and treatment of sarcopenia in chronic liver diseases are poor and conflicting. The aims of this review of the literature are to define sex differences in sarcopenic cirrhotic patients and to highlight the necessity of a sex stratified analysis in future studies. This analysis of the literature showed that most of the studies are retrospective, with a higher prevalence of sarcopenia in males, probably due to anatomical differences between the sexes. Moreover, diagnostic criteria for sarcopenia are different between studies, as there is not a defined cut-off and, as a consequence, no comparable results. In conclusion, sex seems to have an impact on sarcopenia, and future studies must accurately investigate its role in identifying and treating high-risk patients, reducing the negative impact of sarcopenia on the survival and quality of life of cirrhotic patients.
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PMID : 34789397
DOI : 10.1016/j.dld.2021.10.010
Keywords
Sex; Sarcopenia; Liver disease; Gender; Sarcopenia/diagnosis/epidemiology/etiology; Retrospective Studies; Quality of Life; Liver Cirrhosis/complications/diagnosis/epidemiology; Male; Liver Neoplasms/complications/epidemiology; Humans; Female; Carcinoma, Hepatocellular/complications;