Gender Differences and Immunotherapy Outcome in Advanced Lung Cancer. in International journal of molecular sciences / Int J Mol Sci. 2021 Nov 4;22(21):11942. doi: 10.3390/ijms222111942.
2021
ASL Cuneo 1
Tipo pubblicazione
Review
Autori/Collaboratori (5)Vedi tutti...
Vavalà T
ASL CN1, Struttura Complessa di Oncologia, Ospedale di Savigliano, Via Ospedali 9, 12038 Savigliano, Italy.
Catino A
Thoracic Oncology, IRCCS Istituto Tumori "Giovanni Paolo II", Viale O. Flacco 65, 70124 Bari, Italy.
Longo V
Thoracic Oncology, IRCCS Istituto Tumori "Giovanni Paolo II", Viale O. Flacco 65, 70124 Bari, Italy.
et alii...
Abstract
In developed countries, lung cancer is the leading cause of cancer-related death in both sexes. Although cigarette smoking represents the principal risk factor for lung cancer in females, the higher proportion of this neoplasm among non-smoking women as compared with non-smoking men implies distinctive biological aspects between the two sexes. Gender differences depend not only on genetic, environmental, and hormonal factors but also on the immune system, and all these aspects are closely interconnected. In the last few years, it has been confirmed that the immune system plays a fundamental role in cancer evolution and response to oncological treatments, specifically immunotherapy, with documented distinctions between men and women. Consequently, in order to correctly assess cancer responses and disease control, considering only age and reproductive status, the results of studies conducted in female patients would probably not categorically apply to male patients and vice versa. The aim of this article is to review recent data about gender disparities in both healthy subjects' immune system and lung cancer patients; furthermore, studies concerning gender differences in response to lung cancer immunotherapy are examined.
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PMID : 34769372
DOI : 10.3390/ijms222111942
Keywords
lung cancer; immunotherapy; gender differences; Sex Factors; Prognosis; Lung Neoplasms/immunology/pathology/therapy; Immunotherapy/methods; Humans; Animals;