The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective. in Women's health reports (New Rochelle, N.Y.) / Womens Health Rep (New Rochelle). 2022 May 2;3(1):450-457. doi: 10.1089/whr.2021.0124. eCollection 2
2022
AOU Città della Salute di Torino
Tipo pubblicazione
Journal Article
Autori/Collaboratori (22)Vedi tutti...
Zagni E
Novartis Farma S.p.A, Italy.
Ferri F
MediNeos Observational Research, Modena, Italy.
Fiocchi M
MediNeos Observational Research, Modena, Italy.
et alii...
Abstract
BACKGROUND: In psoriasis, several studies have indicated sex differences in clinical characteristics, type of treatment, and outcomes. A higher impact of psoriasis on quality of life (QoL) and a lower treatment satisfaction have been reported in women by different authors. OBJECTIVES: This article reports the results of a post hoc gender analysis of CANOVA study, aimed at assessing 16/24/52-week effectiveness of biologics in patients with moderate-severe plaque psoriasis. MATERIALS AND METHODS: CANOVA was a real-world, multicenter, noninterventional, retro-prospective study conducted in 17 Italian hospital dermatology clinics. RESULTS: Of the 669 eligible patients, 63.8% were men. Demographic and baseline characteristics and duration of disease were rather homogeneous between sexes. Slightly more women had been treated with biologics (50.4% vs. 46.5%) and had received ?2 biologic treatment lines (17.2% vs. 12.4%) before study treatment. The most frequently used biologics were secukinumab, ustekinumab, adalimumab, and ixekizumab in both sexes. At 6 months, Psoriasis Area Severity Index (PASI) 75/90/100 responders were 90.8%/72.3%/45.3% of men and 89.2%/76.6%/48.2% of women. Sustained PASI responders were 79.5% of men and 75.9% of women. Treatment satisfaction was significantly lower in women at enrolment for all subscales, and was still lower at 6 months, no longer significantly. Gender distribution in Dermatology Life Quality Index total score classes showed a significantly greater effect of psoriasis on QoL in women, both at enrolment and at the 6-month follow-up. CONCLUSIONS: In conclusion, this gender analysis confirms in both genders the efficacy of biologics in psoriasis. However, women reported a greater impact of the disease on QoL and lower treatment satisfaction.
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PMID : 35651996
DOI : 10.1089/whr.2021.0124
Keywords
gender differences; efficacy; biologics; QoL; psoriasis;