Prognostic nutritional index (pni) in oncogene addicted advanced non-small cell lung cancer (ansclc) patients (pts): an Italian experience in Clinical Nutrition ESPEN
2021
ASL Torino 3
Tipo pubblicazione
Conference Abstract
Autori/Collaboratori (15)Vedi tutti...
Capizzi I
Morelli AM
Carnio S
et alii...
Abstract
Rationale: PNI is a prognostic factor in lung cancer pts. However, its role in oncogene addicted setting is limited and based on small size trials conducted mainly in Asian and in EGFR-mutated pts. Here we reported our preliminary Results of an Italian single institution experience conduced in oncogene addicted aNSCLC pts treated with tyrosine kinase inhibitors (TKIs). Methods: in oncogene addicted aNSCLC pts (EGFR mutated or other), PNI (10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm3) was evaluated before starting TKIs therapy. The cut-off for the PNI was calculated using the time-dependent receiver operating characteristic (ROC) curve analysis by overall survival (OS) and progression free survival (PFS) predictions. PNI and the clinical/pathologic characteristics were correlated with Pearson’s ? 2 test. Survival curves were made using the Kaplan–Meier method and compared with Log Rank test. Univariate and multivariate analyses were performed using the Cox proportional hazards model. Results: 49 pts were prospectively enrolled. Patients’ characteristics were as follows: median age (range) 67 y (35-84); male/female 12/37; oncogene addiction in EGFR/other 32/17. The PNI cut-off (range) was 37.6 (30.75-51.90). According to PNI value, the preliminary correlation with PFS and OS was hardly accurate (AUC 0.57; HR 0.090; [95% CI 0.393-0.7491] and AUC 0.52; HR 0.092; [95% CI 0.341-0.702]). Higher PNI was more common in pts with age>65y, female gender, EGFR-mutation, even if only the correlation with former smoker habit tended towards statistical significance (p=0.159). Survival curves were still immature. Conclusion: PNI is a promising and easy-to-use tool for nutritional assessment. Its prognostic role in Italian aNSCLC oncogene-dependent patients is still unclear, but our preliminary report could be considered as the basis for further investigation. Disclosure of Interest: I. Capizzi: None declared, A. M. Morelli: None declared, S. Ca
DOI : 10.1016/j.clnesp.2021.09.473
Keywords
ex-smoker; cancer survival; clinical article; conference abstract; consultation; controlled study; drug therapy; statistical significance; receiver operating characteristic; cancer prognosis; cancer patient; adult; advanced cancer; serum albumin; protein tyrosine kinase inhibitor; protease nexin I; epidermal growth factor receptor; endogenous compound; prospective study; progression free survival; prognostic nutritional index; preliminary data; prediction; overall survival; oncogene addiction; nutritional assessment; non small cell lung cancer; male; lymphocyte count; log rank test; Kaplan Meier method; human; gene mutation; gender; female;