LEFT ATRIAL STRAIN AS A PRGONOSTIC MARKER IN ACUTE AND CHRONIC HEART FAILURE : A META-ANALYSIS AND META-REGRESSION ANALYSIS in European Heart Journal, Supplement
2022
AOU Città della Salute di Torino
Tipo pubblicazione
Conference Abstract
Autori/Collaboratori (12)Vedi tutti...
Cameli M
Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
Focardi M
Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
Valente S
Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy
et alii...
Abstract
Background: Heart failure (HF) is a global health burden which prognostic assessment is currently challenging. Speckle tracking echocardiography (STE) has gained increasing importance for the diagnostic and prognostic assessment of HF. Left atrial (LA) strain by STE is widely recognized as an index of diastolic function and left ventricular (LV) filling pressures and fibrosis. Moreover, many studies have investigated its prognostic value in HF with reduced, mildly reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF). Objective: our aim was to systematically investigate the prognostic value of peak atrial longitudinal strain (PALS) for cardiovascular (CV) events in HF and its variation in acute/chronic HF and according to LV function, age and gender. Methods: A systematic literature search of medical databases including Pubmed, Scopus, Ovid Online, EMBASE, Web of Science, Cochrane Central Register, Scopus was performed using PRISMA principles. All relevant studies in English language reporting the predictive value of LA strain for mortality and/or CV events (CV death, hospitalization for HF, cardiac transplant, ventricular assist device implantat) in HFrEF, HFmrEF and HFpEF, with follow up>6 months were identified. All-cause mortality and HF hospitalizations were considered as primary endpoint. Hazard ratios (HR) were performed using a random effect model reporting on the association of global PALS and outcome and described as pooled estimates with 95% confidence intervals (CI). Results: Eight studies (5767 patients, median [IQR] age=66.3 [65;68.6], 37% female) satisfied the inclusion criteria (5 studies chronic HF, 2 studies acute HF, 1 study in acute and chronic HF). Overall, 6 studies included patients with HFrEF, 3 studies patients with HFmrEF and 5 patients with HFpEF. Median global PALS value was 17.6 [14.9;26.8]%, median LVEF was 36 [30;56]% and median LV global longitudinal strain (GLS) was -9 [-7;-16.9]%. Over a median follow up of 903 [3
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DOI : 10.1093/eurheartjsupp/suac121.218
Keywords
acute heart failure; adult; all cause mortality; cardiovascular disease; cardiovascular mortality; clinical practice; Cochrane Library; conference abstract; Embase; English (language); female; follow up; gender; heart failure; heart failure with reduced ejection fraction; heart graft; heart left atrium; heart left ventricle ejection fraction; heart left ventricle function; hospitalization; human; left ventricular global longitudinal strain; male; Medline; meta analysis; mortality; predictive value; publication bias; risk assessment; Scopus; statistical significance; surgery; systematic review; ventricular assist device; Web of Science;