TORNA ALL’ELENCO

S100B maternal blood levels are gestational age-and gender-dependent in healthy pregnancies in Clinical Chemistry and Laboratory Medicine

2017
AOU Alessandria

Tipo pubblicazione

Article

Autori/Collaboratori (10)Vedi tutti...

Conforti E
Epidemiology and Biostatistics Section, Scientific Directorate IRCCS G. Gaslini, Genoa, Italy
Baryshnikova E
Epidemiology and Biostatistics Section, Scientific Directorate IRCCS G. Gaslini, Genoa, Italy
Pluchinotta F
Epidemiology and Biostatistics Section, Scientific Directorate IRCCS G. Gaslini, Genoa, Italy

et alii...

Abstract

S100B is a well-established biomarker of central nervous system (CNS) development and damage in the perinatal period. Because the fetal CNS induces an overproduction of S100B measurable in the maternal bloodstream we evaluated S100B protein in healthy pregnancies in order to provide a reference curve of the protein in the second and third trimesters and to provide information on CNS development when standard monitoring procedures could be silent or unavailable. Between July 2012 and December 2014 we conducted a prospective study in 1213 healthy pregnancies delivering healthy newborns. Maternal blood samples were collected for standard monitoring procedures and S100B assessment. S100B correlations with selected outcomes (gestational age at sampling, gender of fetus, gestational age and weight at birth, delivery mode) were calculated using multiple forward stepwise regression analysis. S100B concentrations in the second and third trimesters of pregnancy were found to be gestational age-, gender-and delivery mode-dependent (p<0.05, for all). Multiple forward stepwise regression analysis with S100B as the dependent variable and gestational age at sampling, gender, delivery mode, gestational age and weight at birth as independent variables, showed a significant correlation between S100B and gestational age at sampling (R=0.13; p<0.001). The present findings offering a S100B protein reference curve in maternal blood suggest that non-invasive fetal CNS monitoring is becoming feasible and open the way to further research in neuro-biomarker assessment in the maternal bloodstream.

PMID : 28282292

DOI : 10.1515/cclm-2016-1127

Keywords

male; human; gestational age; third trimester pregnancy; second trimester pregnancy; protein blood level; prospective study; priority journal; physiologic monitoring; outcome assessment; obstetric delivery; maternal blood; gender identity; female; concentration process; cohort analysis; clinical evaluation; brain development; blood sampling; blood flow; blood analysis; birth weight; biological monitoring; article; adult; protein S100B;