CIRT-induced cardiac biomarkers changes in patients with para/intra-cardiac tumours in Radiotherapy and Oncology

2023
AOU Città della Salute di Torino

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (14)Vedi tutti...

Barcellini A
CNAO National Center for Oncological Hadrontherapy, Radiation Oncology Unit, Clinical Department, Pavia, Italy
Fontana G
CNAO National Center for Oncological Hadrontherapy, Clinical Bioengineering Unit, Clinical Department, Pavia, Italy
Dusi V
AOU Città Della Salute e Della Scienza, University of Turin, Division of Cardiology, Department of Medical Sciences, Torino, Italy

et alii...

Abstract

Purpose or Objective Finding early predictors of late cardiotoxicity after a thoracic RT, which represents a significant risk factor for premature death, is warranted. This study aims to assess the effect of thoracic carbon ion radiotherapy (CIRT) on serum levels of Creactive protein (CRP), troponin-I (TnI) and NT-ProBNP. Materials and Methods Clinical, laboratoristic and dosimetric data from 15 consecutive pts (median age: 67 years, range: 38-79, 53% female) treated with pencil beam CIRT (median total dose 56 Gy [RBE], range: 40-70 Gy [RBE]) for a para/intra-cardiac tumour at a single center were retrospectively reviewed. Most patients (10, 67%) were treated for thoracic localization of sarcomas (leiomyosarcomas N=3, chondrosarcomas N=2, liposarcomas N=2, hemangioendothelioma N=1, fibromyxoid sarcoma N=1, pleomorphic sarcoma N=1), 2 for adenoid cystic carcinomas, the rest for thyroid carcinoma (N=1), renal clear cell carcinomas (N=1) and colon adenocarcinoma (N=1). Laboratoristic parameters were collected before, during, at the end of CIRT and at 3, 6 and 12 months of follow-up (m-FU). Wilcoxon signed-rank test was applied to evaluate changes during treatment (baseline to CIRT-end) and after treatment (CIRT-end to 6m-FU). Any relationship between dosimetric/clinical data and laboratoristic changes over time was explored using Spearman correlation test and point biserial correlation index when appropriate. The significance level was set to 0.05. Results Median FU was 6 months (range: 0 to 12 months). At baseline, diabetes (p= 0,035) and hypercholesterolemia (p=0,023) were associated with higher CRP value; hypercholesterolemia (p=0,045) with higher TnI values; tyroid disease (p<0.001) with higher NT-ProBNP values. Cardiovascular comorbidities, disease history, age and gender did not influence laboratoristic changes during and after CIRT. TnI and CRP values, both within the normal range, were unchanged, while NT-ProBNP values reported a significant increase dur

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DOI : 10.1016/S0167-8140(23)66354-6

Keywords

amino terminal pro brain natriuretic peptide; biological marker; C reactive protein; endogenous compound; troponin I; adenoid cystic carcinoma; aged; cancer patient; cancer radiotherapy; chondrosarcoma; clear cell renal cell carcinoma; clinical article; colon adenocarcinoma; comorbidity; conference abstract; controlled study; coronary artery circumflex branch; diabetes mellitus; female; follow up; gender; heart left atrium; heart tumor; hemangioendothelioma; human; human tissue; hypercholesterolemia; ion therapy; left coronary artery; leiomyosarcoma; liposarcoma; male; maximum permissible dose; medical history; morbidity; mortality; prospective study; protein blood level; protein expression; retrospective study; sarcoma; thyroid carcinoma; Wilcoxon signed ranks test;