TORNA ALL’ELENCO

Prognostic value of left atrial strain by speckle tracking echocardiography in acute and chronic heart failure: a meta-analysis and meta-regression analysis in European Heart Journal Cardiovascular Imaging

2023
AOU Città della Salute di Torino

Tipo pubblicazione

Conference Abstract

Autori/Collaboratori (13)Vedi tutti...

Pastore MC
1Hospital Citta Della Salute e della Scienza di Torino, University of Turin, Division of Internal Medicine, Hypertension Unit, Turin, Italy University Hospital Vall d'Hebron, Cardiology Department, Cardiac Imaging Unit, Aortic Diseases and Inherited Cardiomyopathies, Barcelona, Spain University Hospital Vall d'Hebron, Vall d'Hebron Research Institute, Barcelona, Spain
Mandoli GE
1Hospital Citta Della Salute e della Scienza di Torino, University of Turin, Division of Internal Medicine, Hypertension Unit, Turin, Italy University Hospital Vall d'Hebron, Cardiology Department, Cardiac Imaging Unit, Aortic Diseases and Inherited Cardiomyopathies, Barcelona, Spain University Hospital Vall d'Hebron, Vall d'Hebron Research Institute, Barcelona, Spain
Stefanini A
1University of Siena, Siena, Italy Hospital Citta Della Salute e della Scienza di Torino, Division of Cardiology, Cardiovascular and thoracic Department, Turin, Italy IRCCS Monzino Cardiology Center, Milan, Italy

et alii...

Abstract

Background: Heart failure (HF) is a global health burden which prognostic assessment is currently challenging. Speckle tracking echocardiography (STE) has gained increasing importance for the diagnostic and prognostic assessment of HF. Left atrial (LA) strain by STE is widely recognized as an index of diastolic function and left ventricular (LV) filling pressures and fibrosis. Moreover, many studies have investigated its prognostic value in HF with reduced, mildly reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF). Objective: our aim was to systematically investigate the prognostic value of peak atrial longitudinal strain (PALS) for cardiovascular (CV) events in HF and its variation in acute/chronic HF and according to LV function, age and gender. Methods: A systematic literature search of medical databases including Pubmed, Scopus, Ovid Online, EMBASE, Web of Science, Cochrane Central Register, Scopus was performed using PRISMA principles. All relevant studies in English language reporting the predictive value of LA strain for mortality and/or CV events (CV death, hospitalization for HF, cardiac transplant, ventricular assist device implant) in HFrEF, HFmrEF and HFpEF, with follow up >6 months were identified. All-cause mortality and HF hospitalizations were considered as primary endpoint. Hazard ratios (HR) were performed using a random effect model reporting on the association of global PALS and outcome and described as pooled estimates with 95% confidence intervals (CI). Results: Eight studies (5767 patients, median [IQR] age=66.3 [65;68.6], 37% female) satisfied the inclusion criteria (5 studies chronic HF, 2 studies acute HF, 1 study in acute and chronic HF). Overall, 6 studies included patients with HFrEF, 3 studies patients with HFmrEF and 5 patients with HFpEF. Median global PALS value was 17.6 [14.9;26.8]%, median LVEF was 36 [30;56]% and median LV global longitudinal strain (GLS) was -9 [-7;-16.9]%. Over a median follow up of 903 [32

DOI : 10.1093/ehjci/jead119.424

Keywords

acute heart failure; adult; all cause mortality; cardiovascular disease; cardiovascular mortality; clinical practice; Cochrane Library; conference abstract; Embase; English (language); female; follow up; gender; heart failure; heart failure with reduced ejection fraction; heart graft; heart left atrium; heart left ventricle ejection fraction; heart left ventricle function; hospitalization; human; implant; left ventricular global longitudinal strain; male; Medline; meta analysis; mortality; predictive value; publication bias; risk assessment; Scopus; speckle tracking echocardiography; statistical significance; surgery; systematic review; ventricular assist device; Web of Science;