Impact of transfusion dependency on health-related quality of life outcomes in newly diagnosed patients with myelodysplastic syndromes (MDS). Analysis on 669 patients by disease risk in Blood
2017
ASL Asti
Tipo pubblicazione
Conference Abstract
Autori/Collaboratori (26)Vedi tutti...
Niscola P
Hematology Unit, Sant'Eugenio Hospital, Rome, Italy
Efficace F
Italian Group for Adult Hematologic Diseases (GIMEMA), Data Center and Health Outcomes Research Unit, Rome, Italy
Borin LM
Clinica Ematologica IRCCS AOU San Martino IST, Genova, Italy
et alii...
Abstract
Background: There is some evidence indicating that transfusion dependency negatively impact health-related quality of life HRQOL of patients with myelodysplastic syndromes (MDS). However, there is paucity of evidence-based on this relationship across all different disease risk-group categories. Aims: The primary objective of this study is to examine whether transfusion dependency has a different impact on HRQOL outcomes (ie. functional wellbeing and symptom burden) by disease risk according to the International Prognostic Scoring System (IPSS). Methods: Analysis is based on 669 newly diagnosed MDS patients enrolled in ongoing international prospective observational study. Patients with any IPSS risk score category were consecutively enrolled in 37 centers from nine countries. Patients were invited to participate during one of the first consultations, after confirmed diagnosis of MDS. Multidimensional HRQOL and fatigue outcomes were assessed at baseline (i.e., before treatment) with the well validated European Organization for Research and treatment of Cancer (EORTC) QLQ-C30 and the Functional Assessment of Chronic Illness Therapy ( FACIT ) Fatigue questionnaires. Patients were classified as transfusion dependent (TD) or transfusion independent (TI) using the following definition of “transfusion dependency”: having received at least one red blood cell transfusion every 8 weeks over a period of 4 months (Malcovati L, et al, J Clin Oncol . 2007; 25: 3503-10). We used proportions, means and medians to describe data, by risk and transfusiondependence groups. Possible statistically significant differences between groups were assessed by Fisher and Wilcoxon-Mann-Whitney tests according to the type of variable. We also investigated possible clinically meaningful differences according to previously published guidelines. Results: Median age of the entire cohort (N=669) was of 77 years (range 18-96 years) and there were 418 men (62%) and 251 (38%) women. Of the enti
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Keywords
multicenter study; male; malignant neoplasm; major clinical study; International Prognostic Scoring System; human; education; erythrocyte transfusion; diagnosis; controlled study; consultation; conference abstract; comorbidity; cohort analysis; clinical assessment; chronic disease; adult; high risk population; gender; functional assessment; female; aged; hemoglobin; endogenous compound; fatigue; wellbeing; risk assessment; rank sum test; questionnaire; quality of life; prospective study; practice guideline; physician; pain; observational study; myelodysplastic syndrome;