ALTERNATING HEMIPLEGIA OF CHILDHOOD: AN ELECTROCLINICAL STUDY OF SLEEP AND HEMIPLEGIA in medRxiv
2022
AOU Alessandria
Tipo pubblicazione
Preprint
Autori/Collaboratori (8)Vedi tutti...
Poole J
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom
Zagaglia S
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom
Demurtas R
Neurology and Stroke Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
et alii...
Abstract
Objective: Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect. Methods: We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep. Results: We found 1) hemispheric differences in pre-ictal and ictal spectral power (p=0.034), during AHC hemiplegic episodes 2) 22% reduced beta power (p=0.017) and 26% increased delta power (p=0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls (p=0.0003). Conclusions: There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted. Significance: Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC and is of particular importance when considering risk of sudden unexpected death in epilepsy (SUDEP).
Se sei accreditato in BVS-P effettua l'accesso per utilizzare i nostri servizi.
DOI : 10.1101/2022.05.14.22274850
Keywords
adult; arousal; childhood; clinical article; controlled study; electroencephalogram; epilepsy; female; gender; hemiplegia; human; male; retrospective study; sleep stage; spectroscopy; sudden unexpected death in epilepsy; telemetry; videorecording; wakefulness;