Presence and significant determinants of cognitive impairment in a large sample of patients with multiple sclerosis. in PloS one / PLoS One. 2013 Jul 29;8(7):e69820. doi: 10.1371/journal.pone.0069820. Print 2013.
2013
AOU San Luigi di Orbassano
ASL Torino 3
Tipo pubblicazione
Research Support, Non-U.S. Gov't
Autori/Collaboratori (11)Vedi tutti...
Borghi M
Department of Mental Health, San Luigi Gonzaga Hospital Medical School, University of Turin, ASL TO3, Orbassano, Italy.
Cavallo M
Carletto S
et alii...
Abstract
OBJECTIVES: To investigate the presence and the nature of cognitive impairment in a large sample of patients with Multiple Sclerosis (MS), and to identify clinical and demographic determinants of cognitive impairment in MS. METHODS: 303 patients with MS and 279 healthy controls were administered the Brief Repeatable Battery of Neuropsychological tests (BRB-N); measures of pre-morbid verbal competence and neuropsychiatric measures were also administered. RESULTS: Patients and healthy controls were matched for age, gender, education and pre-morbid verbal Intelligence Quotient. Patients presenting with cognitive impairment were 108/303 (35.6%). In the overall group of participants, the significant predictors of the most sensitive BRB-N scores were: presence of MS, age, education, and Vocabulary. The significant predictors when considering MS patients only were: course of MS, age, education, vocabulary, and depression. Using logistic regression analyses, significant determinants of the presence of cognitive impairment in relapsing-remitting MS patients were: duration of illness (OR?=?1.053, 95% CI?=?1.010-1.097, p?=?0.015),
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PMID : 23922813
DOI : 10.1371/journal.pone.0069820
Keywords
disease duration; disease course; depression; controlled study; demography; cognitive defect; clinical feature; Brief Repeatable Battery; linguistics; intelligence quotient; human; gender; female; Expanded Disability Status Scale; education; article; age; adult; major clinical study; male; multiple sclerosis; neuropsychological test;