Gender-related differences in post-discharge bleeding among patients with acute coronary syndrome on dual antiplatelet therapy: A BleeMACS sub-study. in Thrombosis research / Thromb Res. 2018 Aug;168:156-163. doi: 10.1016/j.thromres.2018.06.022. Epub 2018 Jun 28.
2018
AOU Città della Salute di Torino
Tipo pubblicazione
Journal Article
Autori/Collaboratori (47)Vedi tutti...
Grodecki K
Medical University of Warsaw, Warsaw, Poland.
Huczek Z
Medical University of Warsaw, Warsaw, Poland. Electronic address: zenon.huczek@wum.edu.pl.
Kowara M
Medical University of Warsaw, Warsaw, Poland.
et alii...
Abstract
INTRODUCTION: Bleeding is an independent risk factor of mortality in patients with acute coronary syndromes (ACS). BleeMACS project focuses on long-term bleeding events after hospital discharge, thus we evaluated gender-related differences in post-discharge bleeding among patients with ACS. MATERIALS AND METHODS: We investigated 13,727 ACS patients treated with percutaneous coronary intervention and discharged on dual antiplatelet therapy (either with clopidogrel or prasugrel/ticagrelor). Endpoint was defined as intracranial bleeding or any other bleeding leading to hospitalization and/or red blood transfusion. RESULTS: Post-discharge bleeding was reported more frequently in females as compared with males (3.7% vs. 2.7%, log-rank P?=?0.001). Females (n?=?3165, 23%) were older compared to men (69.0 vs. 61.5?years, P?
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PMID : 30064688
DOI : 10.1016/j.thromres.2018.06.022
Keywords
Acute Coronary Syndrome/drug therapy; Aged; Female; Gender Identity; Hemorrhage/chemically induced; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors/pharmacology/therapeutic use; Risk Factors; Acute myocardial infarction; Antiplatelet agents; Cardiology; Platelet pharmacology;