PMMA dialyzers modulate both humoral and cell-mediate immune response to anti-COVID-19 vaccine (BNT162b2) in a cohort of chronic hemodialyzed patients. in Scientific reports / Sci Rep. 2024 May 28;14(1):12217. doi: 10.1038/s41598-024-62044-9.
2024
ASL Cuneo 1
ASL Cuneo 1
Tipo pubblicazione
Journal Article
Autori/Collaboratori (10)Vedi tutti...
Castellano G
Nephrology, Dialysis and Renal Transplantation Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Commenda 15, 20122, Milan, Italy. giuseppe.castellano@unimi.it.
Netti GS
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. giuseppe.castellano@unimi.it.
Cantaluppi V
Unit of Clinical Pathology, Center for Molecular Medicine and Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
et alii...
Nephrology, Dialysis and Renal Transplantation Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Commenda 15, 20122, Milan, Italy. giuseppe.castellano@unimi.it.
Netti GS
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. giuseppe.castellano@unimi.it.
Cantaluppi V
Unit of Clinical Pathology, Center for Molecular Medicine and Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
et alii...
Abstract
Patients on hemodialysis (HD) have a high risk of death from COVID-19. We evaluated the humoral and cell-mediated immune response to BNT162b2 (Pfizer-BioNTech) vaccine in HD patients, comparing HD with Poly-methyl-methacrylate (PMMA) and HD with Polysulphone (PS). Samples were collected before vaccination (T0) and 14-days after the 2ndvaccine (T2) in a TG (TG, n?=?16-Foggia) and in a VG (CG, n?=?36-Novara). Anti-SARS-CoV-2-Ig were titrated in the cohort 2-weeks after the 2nddose of vaccine. In the Testing-Group, serum neutralizing antibodies (NAb) were assayed and PBMCs isolated from patients were thawed, counted and stimulated with SARS-CoV-2 IGRA stimulation tube set. All patients had a positive ab-response, except in a case. PMMA-patients had higher levels of anti-SARS-CoV-2 IgG (p?=?0.031); VG data confirmed these findings (p?
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PMID : 38806543
DOI : 10.1038/s41598-024-62044-9
Keywords
Humans; Renal Dialysis; Male; Female; Aged; COVID-19/immunology/prevention & control; Middle Aged; Antibodies, Viral/blood/immunology; Immunity, Humoral; BNT162 Vaccine/immunology; Antibodies, Neutralizing/immunology/blood; SARS-CoV-2/immunology; Immunity, Cellular; Polymethyl Methacrylate/chemistry; COVID-19 Vaccines/immunology/administration & dosage; Cohort Studies; Immunoglobulin G/blood/immunology; Aged, 80 and over; Vaccination/methods; Polymers; Sulfones; Cellular immunity; Hemodialysis patients; Humoral immunity; Poly-methyl-methacrylate; SARS-CoV-2 vaccination; Vaccine antibody response;