Medicina di genere

La Medicina di genere ha l’obiettivo di comprendere i meccanismi attraverso i quali le differenze legate al genere agiscono sullo stato di salute e sull’insorgenza e il decorso di molte malattie, nonché sugli outcome delle terapie. Gli uomini e le donne, infatti, pur essendo soggetti alle medesime patologie, presentano sintomi, progressione di malattie e risposta ai trattamenti molto diversi tra loro. Da qui la necessità di porre particolare attenzione allo studio del genere, inserendo questa “nuova” dimensione della medicina in tutte le aree mediche.

Ministero della Salute

AREE TEMATICHE E LETTERATURA

Addiction

• Factors Associated with Sexual Risks and Risk of STIs, HIV and Other Blood-Borne Viruses Among Women Using Heroin and Other Drugs: A Systematic Literature Review.
  Medina-Perucha, Family, Scott J3, Chapman, Dack C.
  AIDS Behav. 2018 Aug 2.
• Gender differences in the impact of population-level alcohol policy interventions: evidence synthesis of systematic reviews.
  Fitzerald N, Angus K, Emslie C, Shipton D, Bauld L.
  Addiction. 2016 Oct;111(10):1735-47 | DOI: 10.1111/add.13452. Epub 2016 Jul 8 Epub 2016 Jul 8.
• Birth cohort trends in the global epidemiology of alcohol use and alcohol-related harms in men and women: systematic review and metaregression.
  T Slade, C Chapman, W Swift, K Keyes, Z Tonks et al.
  BMJ open. 2016; Vol. 6, Issue 10.

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Ageing

• Gender perspectives on views and preferences of older people on exercise to prevent falls: a systematic mixed studies review.
  Sandlund M, Skelton DA, Pohl P, Ahlgren C, Melander-Wikman A, Lundin-Olsson L.
  BMC Geriatr. 2017 Feb 17;17(1):58.
• Racial/Ethnic and gender gaps in the use of and adherence to evidence-based preventive therapies among elderly Medicare Part D beneficiaries after acute myocardial infarction.
  Robinson JG, Oramasionwu C, Fang G.
  Circulation. 2014 Feb 18;129(7):754-63.

Alzheimer’s Deseases

• Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences.
  Mielke, Michelle M.; Vemuri, Prashanthi; Rocca, Walter A.
  CLINICAL EPIDEMIOLOGY 2014;6: 37-48
• Sex and gender differences in caregiving burden experienced by family caregivers of persons with dementia: a systematic review protocol.
  Xiong C, Biscardi M, Nalder E, Colantonio A.
  BMJ Open 2018 Aug 13;8(8)

Bone Diseases

• Is osteoarthritis a gender-specific disease?
  Alberto Migliore, Giovanna Picarelli
  IJGSM 2017;4(1):13-20
  PDF (347,6 kb)

Cardiovascular Diseases

• Thrombotic and hemorrhagic burden in women: Gender-related issues in the response to antithrombotic therapies
  Renda G, Patti G, Lang IM, Siller-Matula JM, Hylek EM, Ambrosio G, Haas S, De Caterina R; Working Group on Thrombosis of the Italian Society of Cardiology.
  International Journal of Cardiology, 2019 Feb 8 | DOI 10.1016/j.ijcard.2019.02.004
  Full Text | PDF (539,0 kb)
• Sex-Specific Cut-Offs for High-Sensitivity Cardiac Troponin: Is Less More?
  Romiti GF, Cangemi R, Toriello F, Ruscio E, Sciomer S, Moscucci F, Vincenti M, Crescioli C, Proietti M, Basili S, Raparelli V
  Cardiovasc Ther 2019 Feb 5;2019:9546931 | DOI 10.1155/2019/9546931.eCollection 2019.
• Cuore. Quello delle giovani donne è diventato più fragile.
  Will Boggs
  Quotidiano Sanità/Popular Science 2018 nov 26
• Twenty Year Trends and Sex Differences in Young Adults Hospitalized with Acute Myocardial Infarction: The ARIC Community Surveillance Study.
  Sameer Arora, George A. (Rick) Stouffer, Anna Kucharska-Newton, Arman Qamar, Muthiah Vaduganathan, Ambarish Pandey, Deborah S Porterfield, Ron Blankstein, Wayne D. Rosamond, Deepak Bhatt, Melissa C Caughey
  Circulation. 2018 nov 11
• To Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications
  Jennifer Abbasi
  JAMA. 2018;320(17):1741-1743
• Sex differences in the presentation and perception of symptoms among young patients with myocardial infarction: evidence from the VIRGO study (Variation in Recovery: role of Gender on Outcomes of young AMI Patients)
  Lichtman JH, Leifheit EC, Safdar B
  Circulation, 2018 Feb 20; 137 (8):781-790 | DOI 10.1161/CIRCULATIONAHA.117.031650
  Full Text | PDF (130,0 kb)
• Conventional vascular and specific risk factors for intracerebral hemorrhage in females
  Fattori di rischio convenzionali e specifici per emorragia cerebrale nelle donne
  Valentina Arnao, Marta Fedele, Riccardo Altavilla, Valeria Caso
  IJGSM 2017;3(3):98-103 | DOI 10.1723/2882.29058
  Full Text | PDF (490,7 kb)
• Gender differences in heart failure
  Differenze di genere nell’insufficienza cardiaca
  Marco Merlo, Vincenzo Nuzzi, Riccardo Bessi, Enrico Fabris, Gianfranco Sinagra
  IJGSM 2017;3(3):141-143 | DOI 10.1723/2924.29392
  Full Text | PDF (433,4 kb)
• Cardiac arrhythmias
  Aritmie cardiache
  Loira Leoni
  IJGSM 2017;3(3):144-145 | DOI 10.1723/2924.29393
  Full Text | PDF (431,8 kb)
• Stroke, gender and sex
  Ictus, genere e sesso
  Francesca Romana Pezzella, Valeria Caso
  IJGSM 2017;3(3):155-157 | DOI 10.1723/2924.29397
  Full Text | PDF (476,7 kb)
• Gender Differences in Epidemiology, Pathophysiology, and Treatment of Hypertension.
  Di Giosia P, Giorgini P, Stamerra CA, Petrarca M, Ferri C, Sahebkar A.
  Curr Atheroscler Rep. 2018 Feb 14;20(3):13
• Racial/Ethnic and gender gaps in the use of and adherence to evidence-based preventive therapies among elderly Medicare Part D beneficiaries after acute myocardial infarction.
  Robinson JG, Oramasionwu C, Fang G.
  Circulation. 2014 Feb 18;129(7):754-63.

Covid-19

• Medicina di genere e COVID-19
  A cura di Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS). Collana Bussole IRCCS
  2 luglio 2020
• The lethal sex gap: COVID-19
  Eladio J. Márquez, Jennifer Trowbridge, […], and Duygu Ucar
  Immun ageing2020; 17:13.
• The impact of sex and gender in the COVID-19 pandemic
  Case study
  Corporate author: Directorate-General for Research and Innovation (European Commission)
  Personal author: Oertelt-Prigione, Sabine.
  ISBN 978-92-76-18883-4; Doi 10.2777/17055.

Diabetes

• Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus.
  Kautzky-Willer, A, Harreiter, J, Pacini, G.
  Endocr Rev 2016;37:278–316

Endocrine Diseases

• Endocrine disruption of androgenic activity by perfluoroalkyl substances: clinical and experimental evidence
  Andrea Di Nisio, Iva Sabovic, Umberto Valente, Simone Tescari, Maria Santa, Rocca Diego, Guidolin, Stefano Dall’Acqua, Laura Acquasaliente, Nicola Pozzi, Mario Plebani, Andrea Garolla, Carlo Foresta
  JCEM 2018 nov 6| DOI 10.1210/jc.2018-01855
  Full Text | PDF (14165 kb)
• Gender in endocrinological diseases: biological and clinical differences
  Malattie endocrinologiche e genere: differenze biologiche e cliniche
  Rosa Lauretta, Massimiliano Sansone, Francesco Romanelli, Marialuisa Appetecchia
  IJGSM 2017;3(3):109-116 | DOI 10.1723/2882.29060
  Full Text | PDF (487,5 kb)

Epidemiology

• Differenze di genere nei dati sanitari in Provincia di Lecce.
  Luana Gualtieri, Cristina Mangia, Serenella Molendini, Fabrizio Quarta, Rodolfo Rollo, Antonello Russo, Antonio Sanguedolce, Maria Lucia Santoro, Fulvia Crimieri, Claudia Sunna e il Tavolo di medicina di genere ASL Lecce

Equity and Suitability

• Lo sviluppo della medicina di genere per garantire equità e appropriatezza della cura.
  Ministero della Salute – Quaderni del Ministero della salute, n. 26. Aprile 2016
• Women’s Health
  AA.VV. – Nature Outlook, 4 ottobre 2017
• La salute di genere in toscana
  ARS Toscana – Novembre 2013

Eye Diseases

• Gender differences in blindness, cataract blindness and cataract surgical coverage in India: a systematic review and meta-analysis
  Manya Prasad, Sumit Malhotra, Mani Kalaivani, Praveen Vashist, Sanjeev K Gupta
  Br J Ophthalmol 2019 Jun 24| DOI 10.1136/bjophthalmol-2018-313562
  Full Text | PDF (790 kb)

Gender Pharmacology

• Gender differences and pharmacovigilance: analysis in the Italian population
  Eleonora Castellana, Maria Rachele Chiappetta, Francesco Cattel
  IJGSM 2017;4(1):27-33
  PDF (347,6 kb)
• Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women.
  Flavia Franconi and Ilaria Campesi
  Br J Pharmacol 2014 Feb;171(3): 580-594
• Guideline for the study and evaluation of gender differences in the clinical evaluation of drugs.
  Department of Health and Human Services (HHS)/Food and Drug Administration (FDA) – 1993

Imaging

• Imaging e le donne: le tappe di una vita.
  ONDA (Osservatorio Nazionale sulla Salute della Donna

Immunology and immune-mediated Diseases

• Immunology and immune-mediated diseases
  Immunologia e malattie immunomediate
  Elena Ortona
  IJGSM 2017;3(4):165-166 | DOI 10.1723/2924.29401
  Full Text | PDF (429,8 kb)
• Immunology and cancer: gender differences
  Immunologia e cancro: differenze di genere
  Anna Maria Di Giacomo, Michele Maio
  IJGSM 2017;3(4):167-168 | DOI 10.1723/2924.29402
  Full Text | PDF (1038,9 kb)
• Gender differences in autoimmune disease.
  Ngo, S. T.; Steyn, F. J.; McCombe, P. A.
  FRONTIERS IN NEUROENDOCRINOLOGY 2014 Aug;35(3): 347-369

Kidney Diseases

• Preeclampsia and risk of end stage kidney disease: A Swedish nationwide cohort study.
  Ali S. Khashan , Marie Evans, Marius Kublickas, Fergus P. McCarthy, Louise C. Kenny, Peter Stenvinkel, Tony Fitzgerald, Karolina Kublickiene
  PLoS Med. 2019. doi: 10.1371/journal.pmed.1002875
• Prevalence and prognostic impact of chronic kidney disease in STEMI from a gender perspective: data from the SWEDEHEART register, a large Swedish prospective cohort.
  Sederholm Lawesson S, Alfredsson J, Szummer K, Fredrikson M, Swahn E.
  BMJ Open 2015 Jun 23;5(6)

Liver Diseases

• Alcohol drinking patterns and liver cirrhosis risk: analysis of the prospective UK Million Women Study.
  Rachel F Simpson, Carol Hermon, Bette Liu, Jane Green, Gillian K Reeves, Valerie Beral, Sarah Floud
  The Lancet 2018 Nov 21

Lungs Diseases

• Lung cancer incidence in young women vs. young men: A systematic analysis in 40 countries.
  Fidler-Benaoudia MM, Torre LA, Bray F, Ferlay J, Jemal A
  Int J Cancer 2020 Feb 5 | DOI 10.1002/ijc.32809

Mental Health and Psychiatric Diseases

• The Psychological Impact of COVID-19 among Women Accessing Family Care Centers during Pregnancy and the Postnatal Period in Italy.
  Lega, I.; Bramante, A.; Lauria, L.; Grussu, P.; Dubini, V.; Falcieri, M.; Ghiani, M.C.; Giordano, A.; Guidomei, S.; Mignuoli, A.D.; et al.
  Int. J. Environ. Res. Public Health 2022, 19, 1983 | DOI: 10.3390/ijerph19041983
• Gender differences in the mental health of unaccompanied refugee minors in Europe: a systematic review.
  Mohwinkel LM, Nowak AC, Kasper A, Razum O.
  BMJ Open 2018 Jul 30;8(7)
• Gender and dementia
  Genere e demenza
  Amalia Cecilia Bruni, Natalia Altomari, Valentina Laganà, Nicoletta Smirne
  IJGSM 2017;3(4):152-154 | DOI 10.1723/2924.29396
  Full Text | PDF (431,9 kb)
• Inclusion of Women and Gender-Specific Analyses in Randomized Clinical Trials of Treatments for Depression
  Weinberger AH, McKee SA,  Mazure CM
  J Womens Health (Larchmt) 2010 Sep;19(9): 1727–1732

Metabolic Diseases

• Association of Normal-Weight Central Obesity With All-Cause and Cause-Specific Mortality Among Postmenopausal Women
  Yangbo Sun, Buyun Liu, Linda G. Snetselaar et al.
  JAMA Netw Open 2019;2(7):e197337. | DOI 10.1001/jamanetworkopen.2019.7337
  Full Text
• Hepatic metabolism and gender
  Metabolismo epatico e differenze di genere
  Adriana Maggi, Sara Della Torre
  IJGSM 2017;3(4):169-170 | DOI 10.1723/2924.29403
  Full Text | PDF (481,0 kb)

Neurodegenerative Diseases

• The role of gender in Parkinson’s disease
  Il ruolo del genere nella malattia di Parkinson
  Marina Picillo, Alessandra Nicoletti, Vincenza Fetoni, Barbara Garavaglia, Maria Teresa Pellecchia
  IJGSM 2017;3(3):104-108 | DOI 10.1723/2882.29059
  Full Text | PDF (468,0 kb)

Oncological Diseases

• Gender differences in lung cancer
  Differenze di genere nel carcinoma polmonare
  Alessandro Dal Maso, Alessandra Ferro, Giulia Pasello
  IJGSM 2017;3(4):146-149 | DOI 10.1723/2924.29394
  Full Text | PDF (440,6 kb)
• Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
  Naugler WE, Sakurai T et al
  Science 06 Jul 2007:Vol.317, Issue 5834, pp. 121-124 | DOI 10.1126/science.1140485
  Full Text | PDF (361,0 kb)

Public Health

• Sicurezza accessibile. La sicurezza sul lavoro in una prospettiva di genere.
  a cura di Giorgio Sclip
  Un volume che raccoglie i contributi del seminario di studi “ La sicurezza sul lavoro in una prospettiva di genere. Uomini e donne sono uguali?”, che si è tenuto l’8 marzo 2018 a Trieste

Reproductive Health

• CERVICAL CANCER PREVENTION POLICY ATLAS
  Autore: European Parliamentary Forum for Sexual & Reproductive Rights
  Anno 2020
• Wintertime Wood Smoke, Traffic Particle Pollution, and Preeclampsia
  Vanessa Assibey-Mensah, J. Christopher Glantz, Philip K. Hopke, Todd A. Jusko, Kelly Thevenet-Morrison, David Chalupa, David Q. Rich
  Hypertension 2020 Jan 6 | DOI 10.1161/HYPERTENSIONAHA.119.13139
  Full Text | PDF (211 kb)
• Endocrine disruption of androgenic activity by perfluoroalkyl substances: clinical and experimental evidence
  Andrea Di Nisio, Iva Sabovic, Umberto Valente, Simone Tescari, Maria Santa, Rocca Diego, Guidolin, Stefano Dall’Acqua, Laura Acquasaliente, Nicola Pozzi, Mario Plebani, Andrea Garolla, Carlo Foresta
  JCEM 2018 nov 6 | DOI 10.1210/jc.2018-01855
  Full Text | PDF (14165 kb)
• To Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications
  Jennifer Abbasi
  JAMA. 2018;320(17):1741-1743

Surgery

• Association of Surgeon-Patient Sex Concordance with Postoperative Outcomes
  Christopher J D Wallis, Angela Jerath, Natalie Coburn, Zachary Klaassen, Amy N Luckenbaugh, Diana E Magee, Amanda E Hird, Kathleen Armstrong, Bheeshma Ravi, Nestor F Esnaola, Jonathan C A Guzman, Barbara Bass, Allan S Detsky, Raj Satkunasivam
  JAMA Surg 2022 Feb 1;157(2):146-156. doi: 10.1001/jamasurg.2021.6339

Viral Infections

• Sex Drives Dimorphic Immune Responses to Viral Infections
  Ghosh S, Klein RS
  JImmunol 2017Mar1;198(5):1782-1790 | DOI 10.4049/jimmunol.1601166
  Full Text | PDF (1071,1 kb)
• Factors Associated with Sexual Risks and Risk of STIs, HIV and Other Blood-Borne Viruses Among Women Using Heroin and Other Drugs: A Systematic Literature Review.
  Medina-Perucha, Family, Scott J3, Chapman, Dack C.
  AIDS Behav. 2018 Aug 2.