Understanding risk factors for endometrial cancer in young women. in Journal of the National Cancer Institute / J Natl Cancer Inst. 2024 Sep 5:djae210. doi: 10.1093/jnci/djae210.
2024
AOU Città della Salute di Torino
AOU Città della Salute di Torino
Tipo pubblicazione
Journal Article
Autori/Collaboratori (49)Vedi tutti...
Peeri NC
Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Bertrand KA
Slone Epidemiology Center and Department of Medicine, Boston University, Boston, MA, USA.
Na R
Population Health Program, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.
et alii...
Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Bertrand KA
Slone Epidemiology Center and Department of Medicine, Boston University, Boston, MA, USA.
Na R
Population Health Program, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.
et alii...
Abstract
BACKGROUND: The American Cancer Society recommends physicians inform average risk women about endometrial cancer (EC) risk on reaching menopause, but new diagnoses are rising fastest in women <50?years. Educating these women about EC risks requires knowledge of risk factors. However, EC in young women is rare and challenging to study in single study populations. METHODS: We included 13,846 incident EC patients (1,639?50?years) and 30,569 matched control individuals from the Epidemiology of Endometrial Cancer Consortium. We used generalized linear models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for 6 risk factors and EC risk. We created a risk score to evaluate the combined associations and population attributable fractions of these factors. RESULTS: In younger and older women, we observed positive associations with BMI and diabetes, and inverse associations with age at menarche, oral contraceptive use, and parity. Current smoking was associated with reduced risk only in women ?50?years (PHet<0.01). BMI was the strongest risk factor [OR?35 vs <25?kg/m2=5.57 (95% CI:4.33-7.16) for <50?years; OR?35 vs <25?kg/m2=4.68 (95% CI : 4.30-5.09) for ?50?years; PHet=0.14]. Possessing ?4 risk factors was associated with ?9-fold increased risk in women <50?years and ?4-fold increased risk in women ?50?years (PHet<0.01). Together, 59.1% of ECs in women <50 and 55.6% in women ?50 were attributable to these factors. CONCLUSIONS: Our data confirm younger and older women share common EC risk factors. Early educational efforts centered on these factors may help mitigate the rising EC burden in young women.
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PMID : 39235934
DOI : 10.1093/jnci/djae210