Candidiasis in Pregnancy: Relevant Aspects of the Pathology for the Mother and the Fetus and Therapeutic Strategies. in Tropical medicine and infectious disease / Trop Med Infect Dis. 2024 May 15;9(5):114. doi: 10.3390/tropicalmed9050114.

2024
ASL Biella

Tipo pubblicazione

Review

Autori/Collaboratori (9)Vedi tutti...

Messina A
Division of Obstetrics and Gynecology, Department of Maternal, Neonatal and Infant Medicine, University Hospital "Degli Infermi", 13875 Ponderano, Italy.
Mariani A
Division of Obstetrics and Gynecology, Department of Maternal, Neonatal and Infant Medicine, University Hospital "Degli Infermi", 13875 Ponderano, Italy.
Brandolisio R
Division of Pediatrics and Neonatology, Department of Maternal, Neonatal and Infant Medicine, University Hospital "Degli Infermi", 13875 Ponderano, Italy.

et alii...

Abstract

Vulvovaginal candidiasis (VVC) is a common condition that can lead to significant discomfort, affecting approximately 70-75% of women at least once in their lives. During pregnancy, the prevalence of VVC is estimated to be around 20%, peaking at about 30% in the third trimester, with a number of specific risk factors predisposing to yeast infection being identified and needing elucidation. This review aims to provide updated knowledge on candidiasis during pregnancy, addressing risk factors and maternal and neonatal outcomes, as well as discussing optimal therapeutic strategies to safeguard mothers and newborns. The bibliographic search involved two biomedical databases, PubMed and Embase, without imposing time limits. Among all Candida spp., Candida albicans remains the most frequent causative species. The hyperestrogenic environment of the vaginal mucosa and reduced immune defenses, physiological effects of pregnancy, create conditions favorable for Candida spp. vaginal colonization and hence VVC. Recent evidence shows an association between VVC and adverse obstetric outcomes, including premature membrane rupture (PROM), chorioamnionitis, preterm birth, and puerperal infections. Prompt and effective management of this condition is therefore crucial to prevent adverse obstetric outcomes, maternal-fetal transmission, and neonatal disease. Additional studies are required to confirm the benefits of systemic treatment for maternal candida infection or colonization in preventing premature birth or neonatal systemic candidiasis.

Accesso banca dati bibliografica

PMID : 38787047

DOI : 10.3390/tropicalmed9050114

Keywords

candida; candidiasis; newborn; pregnancy; transmission; treatment outcome;