Diagnosis of hepatic steatosis and steatohepatitis in people with new-onset type 2 diabetes: a multidisciplinary approach. in Endocrine / Endocrine. 2024 May;84(2):412-419. doi: 10.1007/s12020-024-03715-5. Epub 2024 Feb 12.

2024
ASL Biella

Tipo pubblicazione

Journal Article

Autori/Collaboratori (5)Vedi tutti...

Barana L
Diabetology and Endocrinology, Nuovo Ospdale degli Infermi di Biella, Ponderano, Biella, 13875, Italy. luisa.barana@gmail.com.
Nelva A
Section of Endocrinology and Metabolism, Department of Medicine, University of Perugia, Piazzale Gambuli 1, Perugia, 06129, Italy. luisa.barana@gmail.com.
Scivetti P
Diabetology and Endocrinology, Nuovo Ospdale degli Infermi di Biella, Ponderano, Biella, 13875, Italy.

et alii...

Abstract

AIMS: Non-Alcoholic-Fatty-Liver-Disease (NAFLD) is the most common cause of chronic liver disease in Western countries; closely linked to obesity and type 2 diabetes (T2DM), it is an additional cardiovascular risk factor. The aim of this study is to investigate the prevalence of NAFLD at T2DM onset. METHODS: 122 newly diagnosed T2DM patients were enroled; NAFLD was diagnosed using ultrasound and fibrosis risk calculated with an FIB4-score. Intermediate and high-risk patients were referred to a hepatologist and underwent transient elastography (TE). RESULTS: At T2DM diagnosis, 25% of patients were overweight, 47% were obese; ultrasound steatosis was present in 79% of patients; the average FIB-4 score was 1.4 (0.7). The NAFLD population was characterised by higher presence of obesity (60%, p 0.06); hypertension (56%, p 0.00); AST (26.3 (23.6) UI/L; p 0.00); ALT (49.3(41.0) UI/L p 0.00); FIB-4 score (1.6 (0.8); p 0.00). Among patients referred to a hepatologist, at TE, 65% had severe steatosis, 22% significant fibrosis and 25% advanced fibrosis. CONCLUSION: This is the first proposal of a NAFLD screening model at T2DM diagnosis. The high prevalence of fibrosis found at the early stage T2DM confirms the compelling need for early management of NAFLD through cost-effective screening and long-term monitoring algorithms.

Accesso banca dati bibliografica

PMID : 38347338

DOI : 10.1007/s12020-024-03715-5

Keywords

Humans; Diabetes Mellitus, Type 2/complications/epidemiology; Male; Female; Middle Aged; Non-alcoholic Fatty Liver Disease/epidemiology/complications/diagnosis/diagnostic imaging; Elasticity Imaging Techniques; Aged; Prevalence; Adult; Ultrasonography; Obesity/complications/epidemiology; Risk Factors; Fatty Liver/epidemiology/complications/diagnosis/diagnostic imaging; NAFLD; NASH; New onset diabetes; Steatosis;