Lifestyle Modulators of Neuroplasticity in Parkinson's Disease: Evidence in Human Neuroimaging Studies. in CNS & neurological disorders drug targets / CNS Neurol Disord Drug Targets. 2024;23(5):602-613. doi: 10.2174/1871527322666230616121213.

2024
ASL Città di Torino
ASL Vercelli

Tipo pubblicazione

Review

Autori/Collaboratori (6)Vedi tutti...

Paola Caminiti S
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Gallo S
Neurology Unit, Department of Translational Medicine, Movement Disorders Centre, University of Piemonte Orientale, 28100 Novara, Italy.
Menegon F
Neurology Unit, Department of Translational Medicine, Movement Disorders Centre, University of Piemonte Orientale, 28100 Novara, Italy.

et alii...

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized by both motor and non-motor symptoms. A progressive neuronal loss and the consequent clinical impairment lead to deleterious effects on daily living and quality of life. Despite effective symptomatic therapeutic approaches, no disease-modifying therapies are currently available. Emerging evidence suggests that adopting a healthy lifestyle can improve the quality of life of PD patients. In addition, modulating lifestyle factors can positively affect the microstructural and macrostructural brain levels, corresponding to clinical improvement. Neuroimaging studies may help to identify the mechanisms through which physical exercise, dietary changes, cognitive enrichment, and exposure to substances modulate neuroprotection. All these factors have been associated with a modified risk of developing PD, with attenuation or exacerbation of motor and non-motor symptomatology, and possibly with structural and molecular changes. In the present work, we review the current knowledge on how lifestyle factors influence PD development and progression and the neuroimaging evidence for the brain structural, functional, and molecular changes induced by the adoption of positive or negative lifestyle behaviours.

Accesso banca dati bibliografica

PMID : 37326116

DOI : 10.2174/1871527322666230616121213

Keywords

physical exercise; diet; neuroplasticity.; Neurodegeneration; PET; cognitive reserve; MRI; Exercise/physiology; Quality of Life; Brain/diagnostic imaging; Neuronal Plasticity/physiology; Life Style; Neuroimaging/methods; Parkinson Disease/diagnostic imaging; Humans; smoking;