The pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study. in Surgical oncology / Surg Oncol. 2024 Jun;54:102081. doi: 10.1016/j.suronc.2024.102081. Epub 2024 Apr 26.

2024
ASL Biella
ASL Vercelli
AOU Città della Salute di Torino
ASL Torino 3

Tipo pubblicazione

Multicenter Study

Autori/Collaboratori (39)Vedi tutti...

Di Benedetto F
Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Coratti A
Department of General and Emergency Surgery, Misericordia Hospital, Azienda Usl Toscana Sud Est, School of Robotic Surgery, Grosseto, Italy.
Montuori M
Department of Surgery, Ponte San Pietro Hospital, Bergamo, Italy.

et alii...

Abstract

BACKGROUND: In this article we aimed to perform a subgroup analysis using data from the COVID-AGICT study, to investigate the perioperative outcomes of patients undergoing surgery for pancreatic cancers (PC) during the COVID-19 pandemic. METHODS: The primary endpoint of the study was to find out any difference in the tumoral stage of surgically treated PC patients between 2019 and 2020. Surgical and oncological outcomes of the entire cohort of patients were also appraised dividing the entire peri-pandemic period into six three-month timeframes to balance out the comparison between 2019 and 2020. RESULTS: Overall, a total of 1815 patients were surgically treated during 2019 and 2020 in 14 Italian surgical Units. In 2020, the rate of patients treated with an advanced pathological stage was not different compared to 2019 (p = 0.846). During the pandemic, neoadjuvant chemotherapy (NCT) has dropped significantly (6.2% vs 21.4%, p < 0.001) and, for patients who didn't undergo NCT, the latency between diagnosis and surgery was shortened (49.58 ± 37 days vs 77.40 ± 83 days, p < 0.001). During 2020 there was a significant increase in minimally invasive procedures (p < 0.001). The rate of postoperative complication was the same in the two years but during 2020 there was an increase of the medical ones (19% vs 16.1%, p = 0.001). CONCLUSIONS: The post-pandemic dramatic modifications in healthcare provision, in Italy, did not significantly impair the clinical history of PC patients receiving surgical resection. The present study is one of the largest reports available on the argument and may provide the basis for long-term analyses.

Accesso banca dati bibliografica

PMID : 38729088

DOI : 10.1016/j.suronc.2024.102081

Keywords

Surgery; SARS-CoV2; Pancreatic ductal adenocarcinoma; Pancreatic cancer; Pandemics; COVID-19 pandemic; Prognosis; Follow-Up Studies; Postoperative Complications/epidemiology; Pancreatectomy; Neoadjuvant Therapy; SARS-CoV-2; Middle Aged; Aged; Female; Male; Italy/epidemiology; COVID-19/epidemiology; Pancreatic Neoplasms/surgery/pathology/epidemiology; Humans;