Inclisiran for fast-track lipid-lowering treatment early after an acute coronary syndrome: a pilot study in Atherosclerosis Plus

2025
ASL Torino 4
ASL Asti
ASL VCO

Tipo pubblicazione

Article

Autori/Collaboratori (11)Vedi tutti...

Lupi A
Cardiology Division, ASL14 Verbano-Cusio-Ossola, San Biagio Hospital, Domodossola, Italy
Baluci M
Cardiology Division, ASL14 Verbano-Cusio-Ossola, San Biagio Hospital, Domodossola, Italy
Persampieri S
Cardiology Division, ASL14 Verbano-Cusio-Ossola, San Biagio Hospital, Domodossola, Italy

et alii...

Abstract

Background: Elevated low-density lipoprotein cholesterol (LDL-C) after acute coronary syndrome (ACS) significantly increases cardiovascular risk. Timely reduction of LDL-C is crucial, but it takes several weeks to achieve optimal LDL-C levels with standard therapy. Monoclonal antibodies that inhibit PCSK9 have been demonstrated in some small randomised trials to rapidly abate LDL-C levels when used early after hospital admission for ACS. Inclisiran, a PCSK9-inhibiting siRNA, has recently been introduced into clinical practice; however, no information is available about its effectiveness and safety as a fast-track lipid-lowering agent in this clinical context. Methods: We conducted a prospective, real-world study evaluating a fast-track lipid-lowering approach starting inclisiran on top of standard therapy in 16 consecutive ACS patients admitted to our cardiac intensive care unit with a high baseline LDL-C level (147.2 ± 35.7 mg/dL). Patients started inclisiran as add-on therapy as soon as baseline LDL-C levels were available. We assessed LDL-C levels and the mean change of LDL-C at baseline, discharge, 15-day and 30-day follow-up. Results: Inclisiran, added to standard therapy, reduced LDL-C levels to 30.3 ± 13.0 mg/dL at 30-day follow-up. The guideline-recommended LDL-C levels (?55 mg/dL, ?50 % reduction) were achieved in 73.3 % of patients at 15 days and in 100 % of patients at 30 days, with no adverse effects. Conclusion: This pilot study shows promise for inclisiran as a novel therapeutic option to improve cardiovascular outcomes in patients with ACS by contributing to achieving an early and sustained reduction in LDL-C levels.

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DOI : 10.1016/j.athplu.2025.09.005

Keywords

antilipemic agent; atorvastatin; ezetimibe; inclisiran; low density lipoprotein cholesterol; rosuvastatin; acute coronary syndrome; adult; article; cardiovascular risk; clinical practice; coronary care unit; female; follow up; hospital admission; human; lipid blood level; male; prospective study; unstable angina pectoris;